ArticleJournal of natural medicines2020
Hepatoprotective effects of vicenin-2 and scolymoside through the modulation of inflammatory pathways.
Article in Journal of natural medicines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 20 citations in OpenAlex.
- Total flavonoids fromAnimal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
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- Anti-ageing and attenuating cognitive declines of Dicliptera chinensis extracts and purified compounds in vitro and in scopolamine-induced cognitive dysfunction mice.Botanical studies · 2025Article
- Neuroprotective and antioxidant potential of papaya leaf extract and its active compounds via Nrf-2 activation.Food science and biotechnology · 2025Article
- Anti-Hangover and Hepatoprotective Effects of the Leaf Extract ofPharmaceuticals (Basel, Switzerland) · 2025Article
- Xanthine oxidase inhibition study of isolated secondary metabolites fromSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024Article
- Qualitative and quantitative chemical analysis ofFrontiers in chemistry · 2024Article
- Protective Effects ofFrontiers in veterinary science · 2022Article
- Isoschaftoside Reverses Nonalcoholic Fatty Liver Disease via Activating AutophagyEvidence-based complementary and alternative medicine : eCAM · 2022Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to investigate the effects of two structurally related flavonoids found in Cyclopia subternata, vicenin-2 (VCN) and scolymoside (SCL) on lipopolysaccharide (LPS)-induced liver failure in mice and to elucidate underlying mechanisms. Mice were treated intravenously with VCN or SCL at 12 h after LPS treatment. LPS significantly increased mortality, serum levels of alanine transaminase, aspartate transaminase, and inflammatory cytokines, and toll-like receptor 4 (TLR4) protein expression; these effects of LPS were inhibited by VCN or SCL. It also attenuated the LPS-induced activation of myeloid differentiation primary response gene 88 and TLR-associated activator of interferon-dependent signaling pathways of the TLR system. Our results suggest that VCN or SCL protects against LPS-induced liver damage by inhibiting the TLR-mediated inflammatory pathway, indicating its potential to treat liver diseases.
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Registered trials
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