SynthesisArchives of gynecology and obstetrics2019
Prevention and treatment of uncomplicated lower urinary tract infections in the era of increasing antimicrobial resistance-non-antibiotic approaches: a systemic review.
Synthesis in Archives of gynecology and obstetrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 119 citations in OpenAlex.
- Estrogen for the prevention of recurrent urinary tract infections in postmenopausal women: a meta-analysis of randomized controlled trials.International urogynecology journal · 2021Pooled it
- Trial
- Pharmacists' Management of Urinary Tract Infection Symptoms in Community Pharmacy: Counseling Practices and Attitudes Toward Antibiotic Therapy.Pharmacy (Basel, Switzerland) · 2026Article
- Article
- A comprehensive review on herbal approaches for treatment of urinary tract infections: Scope and challenges.Journal of pharmaceutical analysis · 2026Review
- The Role of Vitamins in Pediatric Urinary Tract Infection: Mechanisms and Integrative Strategies.Biomolecules · 2025Review
- Patient-reported therapeutic benefits of herbal medicinal products in the treatment of gynecological ailments.BMC complementary medicine and therapies · 2025Article
- A Precision Medicine Model for Targeted Antibiotic Therapy in Urinary Tract Infections: A Valuable Tool to Reduce Hospitalization Stay and the Time to Switch to Oral Treatment.Antibiotics (Basel, Switzerland) · 2025Article
- The role of pharmacological interventions in managing urological complications during pregnancy and childbirth: A review.Medicine · 2025Review
- New evidence for content validity of the German version of the Acute Cystitis Symptom Score: cognitive interview study among patients and experts.World journal of urology · 2025Article
- Immunoprophylaxis with MV140 Is Effective in the Reduction of Urinary Tract Infections-A Prospective Real-Life Study.Vaccines · 2024Article
- Relationship between urinary tract infections and serum vitamin D level in adults and children- a literature review.Molecular biology reports · 2024Review
- Polyvalent Bacterial Lysate with Potential Use to Treatment and Control of Recurrent Urinary Tract Infections.International journal of molecular sciences · 2024Article
- Plant phenolics inhibit focal adhesion kinase and suppress host cell invasion by uropathogenicInfection and immunity · 2024Article
- Resistance to first-line antibiotic therapy among patients with uncomplicated acute cystitis in Melbourne, Australia: prevalence, predictors and clinical impact.JAC-antimicrobial resistance · 2024Article
- Antibiotic resistance in urinary tract infections: A study on trends and contributing factors in outpatient care among Indian patients.Bioinformation · 2024Article
- Clinical pharmacists' involvement in carbapenem antibiotics management at Wenzhou Integrated Hospital.World journal of clinical cases · 2023Article
- Development of quality indicators for the diagnosis and treatment of urinary tract infections in general practice: a RAND appropriateness method.BMJ open quality · 2023Article
- Antimicrobial Activity of Spices Popularly Used in Mexico against Urinary Tract Infections.Antibiotics (Basel, Switzerland) · 2023Review
- Psychosocial burden and healthcare disillusionment in recurrent UTI: a large-scale international survey of patient perspectives.Frontiers in urology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeUrinary tract infections (UTIs) are one of the more common infections encountered in everyday clinical practice. They account for 10-20% of all infections treated in primary care units and 30-40% of those treated in hospitals. The risk of UTI in the female population is considered to be 14 times higher than in the male population. The prevalence of bacterial etiology results in a large consumption of broad-spectrum antibiotics, which in turn leads to increased rates of resistant uropathogens. Therefore, non-antibiotic prevention and treatment options are now of great importance.
methodsA systematic literature search was performed for the last 20 years (1999-2019) and the efficiencies of these eight different non-antibiotic interventions were analysed and discussed.
resultsThis article provides an overview on non-antibiotic options for management of UTI, including the application of cranberry products, the phytodrug Canephron N, probiotics, nonsteroidal anti-inflammatory drugs (NSAID), D-mannose, estrogens, vitamins, and immunotherapy.
conclusionsThe last 20 years of research on non-antibiotic approaches in UTI have not brought conclusive evidence that antibiotic usage can be replaced completely by non-antibiotic options. Hence, antibiotics still remain a gold standard for UTI treatment and prevention. However, changing the therapeutic strategy by including non-antibiotic measures in the management of UTI could be successful in avoiding antimicrobial resistance at least to some extent.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.