Evidence map›Paper›PMID 31350620›Full record

ArticleAnnals of biomedical engineering2020

Acoustic Emissions as a Non-invasive Biomarker of the Structural Health of the Knee.

Daniel C Whittingslow, Hyeon-Ki Jeong, Venu G Ganti, Nathan J Kirkpatrick, Geza F Kogler, Omer T Inan

Abstract read
In one paragraph

Article in Annals of biomedical engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Spine Sound Classification: An Explainable Machine Learning Approach.IEEE open journal of engineering in medicine and biology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. A Feasibility Study on Tribological Origins of Knee Acoustic Emissions.IEEE transactions on bio-medical engineering · 2022
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Digitizing clinical trials.NPJ digital medicine · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Daniel C WhittingslowCoulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA. dcwhitt@emory.edu.ORCID http://orcid.org/0000-0003-4399-7579
Hyeon-Ki JeongSchool of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, USA.
Venu G GantiSchool of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, USA.
Nathan J KirkpatrickCoulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
Geza F KoglerSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.
Omer T InanCoulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM008169 · NIGMS · EMORY UNIVERSITY · PI GROSS, ROBERT E · 1987 to 2021
$20.3M
Wearable lung sounds, fluid, and body temperature monitoring for patients with COVID-19R01EB023808 · NIBIB · GEORGIA INSTITUTE OF TECHNOLOGY · PI INAN, OMER TOLGA · 2016 to 2020
$2.2M
Developing animal models for diseases using RNAiR21AG023808 · NIA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI XU, ZUOSHANG · 2004 to 2005
$347k
National Institutes of Health, National Institute of Biomedical Imaging and Bioengineering 1R01EB023808NIBIB NIH HHS R01 EB023808NIGMS NIH HHS T32 GM008169
6 · The paper itself

Abstract

The longitudinal assessment of joint health is a long-standing issue in the management of musculoskeletal injuries. The acoustic emissions (AEs) produced by joint articulation could serve as a biomarker for joint health assessment, but their use has been limited by a lack of mechanistic understanding of their creation. In this paper, we investigate that mechanism using an injury model in human lower-limb cadavers, and relate AEs to joint kinematics. Using our custom joint sound recording system, we recorded the AEs from nine cadaver legs in four stages: at baseline, after a sham surgery, after a meniscus tear, and post-meniscectomy. We compare the resulting AEs using their b-values. We then compare joint anatomy/kinematics to the AEs using the X-ray reconstruction of moving morphology (XROMM) technique. After the meniscus tear the number and amplitude of the AE peaks greatly increased from baseline and sham (b-value = 1.33 ± 0.15; p < 0.05). The XROMM analysis showed a close correlation between the minimal inter-joint distances (0.251 ± 0.082 cm during extension, 0.265 ± .003 during flexion, at 145°) and a large increase in the AEs. This work provides key insight into the nature of joint AEs, and details a novel technique and analysis for recording and interpreting these biosignals.

Indexed as

AcousticsKnee JointAgedBiomarkersCadaverHumansLower ExtremityMiddle AgedBiomarkersCadaver modelDiagnosticMusculoskeletal assessmentPredictivePrognostic markersWearable sensingXROMM

Identifiers

PMID31350620
PMCPMC6930345

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.