ArticleMolecular biology and evolution2019
Population Gene Introgression and High Genome Plasticity for the Zoonotic Pathogen Streptococcus agalactiae.
Article in Molecular biology and evolution, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Comparative Genomic Analysis of Bovine and Publicly Available HumanAnimals : an open access journal from MDPI · 2026Article
- Home is where the host is: evolutionary history of geographic spread, host switching and adaptive genomic signatures in two generalist group BMicrobial genomics · 2026Article
- Integrated analysis of transposon insertion sequencing and pangenome reveals core and lineage-specific essential genes inMicrobial genomics · 2026Article
- Zoonotic Approach toInternational journal of microbiology · 2026Article
- Towards a holistic epidemiology ofFrontiers in bioinformatics · 2026Article
- Integrating natural language processing and genome analysis enables accurate bacterial phenotype prediction.NAR genomics and bioinformatics · 2025Article
- Introgression impacts the evolution of bacteria, but species borders are rarely fuzzy.Nature communications · 2025Article
- Streptococcus abundance and oral site tropism in humans and non-human primates reflects host and lifestyle differences.NPJ biofilms and microbiomes · 2025Article
- Co-evolution and Gene Transfers Drive Speciation Patterns in Host-Associated Bacteria.Molecular biology and evolution · 2024Article
- Group B Streptococcus Sequence Type 103 as Human and Bovine Pathogen, Brazil.Emerging infectious diseases · 2024Article
- Genomic and functional determinants of host spectrum in Group B Streptococcus.PLoS pathogens · 2024Article
- Emergence of Group B Streptococcus Disease in Pigs and Porcupines, Italy.Emerging infectious diseases · 2024Article
- Characteristics of Streptococcus agalactiae belonging to CC103 clone circulating among dairy herds and pregnant women in Brazil.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023Article
- Genomic characterization of emerging invasive Streptococcus agalactiae serotype VIII in Alberta, Canada.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2023Article
- Geographical, Temporal and Host-Species Distribution of Potentially Human-Pathogenic Group BPathogens (Basel, Switzerland) · 2023Article
- Prevalence of multidrug-resistant coagulase-positive staphylococci in canine and feline dermatological patients over a 10-year period: a retrospective study.Microbiology (Reading, England) · 2023Article
- Dispersal history and bidirectional human-fish host switching of invasive, hypervirulent Streptococcus agalactiae sequence type 283.PLOS global public health · 2023Article
- How GBS Got Its Hump: Genomic Analysis of Group BPathogens (Basel, Switzerland) · 2022Article
- Circulation ofApplied and environmental microbiology · 2022Article
- Whole genome sequences reveal the Xanthomonas perforans population is shaped by the tomato production system.The ISME journal · 2022Article
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Authors and funding
12 authors.
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Abstract
The influence that bacterial adaptation (or niche partitioning) within species has on gene spillover and transmission among bacterial populations occupying different niches is not well understood. Streptococcus agalactiae is an important bacterial pathogen that has a taxonomically diverse host range making it an excellent model system to study these processes. Here, we analyze a global set of 901 genome sequences from nine diverse host species to advance our understanding of these processes. Bayesian clustering analysis delineated 12 major populations that closely aligned with niches. Comparative genomics revealed extensive gene gain/loss among populations and a large pan genome of 9,527 genes, which remained open and was strongly partitioned among niches. As a result, the biochemical characteristics of 11 populations were highly distinctive (significantly enriched). Positive selection was detected and biochemical characteristics of the dispensable genes under selection were enriched in ten populations. Despite the strong gene partitioning, phylogenomics detected gene spillover. In particular, tetracycline resistance (which likely evolved in the human-associated population) from humans to bovine, canines, seals, and fish, demonstrating how a gene selected in one host can ultimately be transmitted into another, and biased transmission from humans to bovines was confirmed with a Bayesian migration analysis. Our findings show high bacterial genome plasticity acting in balance with selection pressure from distinct functional requirements of niches that is associated with an extensive and highly partitioned dispensable genome, likely facilitating continued and expansive adaptation.
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