Evidence map›Paper›PMID 31350520›Full record

ArticleScientific reports2019

The influence of Echinacea purpurea leaf microbiota on chicoric acid level.

Valentina Maggini, Marinella De Leo, Carlotta Granchi, Tiziano Tuccinardi, Alessio Mengoni, Eugenia Rosaria Gallo, Sauro Biffi, Renato Fani, Luisa Pistelli, Fabio Firenzuoli and 1 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
5.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
  2. Inoculum of EndophyticPlants (Basel, Switzerland) · 2025
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  4. Antimicrobial Activity ofMolecules (Basel, Switzerland) · 2024
    Review
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  8. Determination of the Bioactive Compounds fromMolecules (Basel, Switzerland) · 2023
    Article
  9. Genomic, Molecular, and Phenotypic Characterization ofInternational journal of molecular sciences · 2023
    Article
  10. Article
  11. Article
  12. Plants (Basel, Switzerland) · 2022
    Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Valentina MagginiDepartment of Biology, University of Florence, Via Madonna del Piano 6, 50019, Sesto Fiorentino, Italy. valentina.maggini@unifi.it.ORCID http://orcid.org/0000-0002-4227-7214
Marinella De LeoDepartment of Pharmacy, University of Pisa, Via Bonanno 6 and 33, 56126, Pisa, Italy.
Carlotta GranchiDepartment of Pharmacy, University of Pisa, Via Bonanno 6 and 33, 56126, Pisa, Italy.
Tiziano TuccinardiDepartment of Pharmacy, University of Pisa, Via Bonanno 6 and 33, 56126, Pisa, Italy.ORCID http://orcid.org/0000-0002-6205-4069
Alessio MengoniDepartment of Biology, University of Florence, Via Madonna del Piano 6, 50019, Sesto Fiorentino, Italy.ORCID http://orcid.org/0000-0002-1265-8251
Eugenia Rosaria GalloDepartment of Experimental and Clinical Medicine, University of Florence, Largo Brambilla 3, 50134, Florence, Italy.
Sauro BiffiBotanical Garden Casola Valsenio, Via del Corso 6, 48010, Ravenna, Italy.
Renato FaniDepartment of Biology, University of Florence, Via Madonna del Piano 6, 50019, Sesto Fiorentino, Italy.
Luisa PistelliDepartment of Pharmacy, University of Pisa, Via Bonanno 6 and 33, 56126, Pisa, Italy.
Fabio FirenzuoliReferring Center for Phytotherapy, Tuscany Region, Careggi University Hospital, Largo Brambilla 3, 50134, Florence, Italy.
Patrizia BoganiDepartment of Biology, University of Florence, Via Madonna del Piano 6, 50019, Sesto Fiorentino, Italy.ORCID http://orcid.org/0000-0002-1679-2458
University of Pisa · ITAzienda Ospedaliero-Universitaria Careggi · ITUniversity of Florence · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The controversial anti-proliferative effects of Echinacea purpurea (L.) Moench (Asteraceae) might be related to different plant metabolites contained in plant samples, extracts and products. The influence of bacterial endophytes on the synthesis of bioactive compounds in the medicinal plants has been previously demonstrated but there are only few studies addressing anticancer effects and mechanisms of E. purpurea extracts following endophytic colonization. The present study aimed to test and compare the lactate dehydrogenase (LDH) inhibition potential of n-hexane and methanol extracts from in vitro endophyte non-inoculated and inoculated E. purpurea plants. An in vitro model was previously set up to perform the infection of axenic E. purpurea plants with bacterial endophytic strains isolated from E. purpurea aerial part. Only methanol extracts showed LDH5 inhibition, in particular the richest in chicoric acid and most strongly inhibiting extract was obtained from inoculated stem and leaves of E. purpurea (IC

Indexed as

MicrobiotaAntineoplastic Agents, PhytogenicBiological TherapyCaffeic AcidsDrug DiscoveryEchinaceaHost-Pathogen InteractionsHumansInhibitory Concentration 50L-Lactate DehydrogenaseNeoplasmsPlant ExtractsPlant LeavesPlants, MedicinalSuccinatesAntineoplastic Agents, PhytogenicCaffeic Acidschicoric acidL-Lactate DehydrogenasePlant ExtractsSuccinates

Identifiers

PMID31350520
PMCPMC6659708
OpenAlexW2964814579

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.