ReviewNature reviews. Clinical oncology2019
Comorbid chronic diseases and cancer diagnosis: disease-specific effects and underlying mechanisms.
Review in Nature reviews. Clinical oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04764695 (Evaluation of Body Composition and Nutritional Status in Pediatric Patients With Hematological Malignancies), which is not on this map. Cited by 108 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Body Composition and Nutritional Status in Pediatric Patients With Hematological Malignancies
Who cites it
108 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Tobacco Use, Stigma, and Coping in Lung Cancer: A Systematic Review of Their Psychosocial Interactions and Clinical Implications.Current oncology (Toronto, Ont.) · 2026Pooled it
- Pooled it
- The Impact of Morbidity and Disability on Attendance at Organized Breast Cancer-Screening Programs: A Systematic Review and Meta-Analysis.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2022Pooled it
- Multimorbidity in Patients With Acute Coronary Syndrome Is Associated With Greater Mortality, Higher Readmission Rates, and Increased Length of Stay: A Systematic Review.The Journal of cardiovascular nursingPooled it
- Symptom Attribution, Help Seeking and Willingness to Undergo Diagnostic Investigations for Bowel Cancer Symptoms in People With Anxiety and/or Depression-A Vignette Study.Psycho-oncology · 2025Trial
- Performance of a Cell-Free DNA-Based Multi-cancer Detection Test in Individuals Presenting With Symptoms Suspicious for Cancers.JCO precision oncology · 2023Trial
- Cardiovascular Phenotypes Across Major Cancer Types: Distribution and Association with All-Cause Mortality in a Retrospective Cohort Study.Diagnostics (Basel, Switzerland) · 2026Article
- Diabetes mellitus is associated with earlier detection of posterior uveal melanoma.European journal of ophthalmology · 2026Article
- Article
- Prevalence of Cardiovascular Disease and Risk Factors Among Cancer Patients: 5-Year National Inpatient Sample Analysis.JACC. Advances · 2026Article
- Endothelial dysfunction determines vascular mechanisms of metastatic progression in breast cancer.Discover oncology · 2026Review
- Cancer-related deaths among cases referred for forensic evaluation in Türkiye: a 5-year retrospective analysis.Revista da Associacao Medica Brasileira (1992) · 2026Article
- Associations between childhood adverse experiences and medication adherence in asthma patients: a dual variable-centered and person-centered analysis of attachment security and mentalization.Frontiers in psychiatry · 2026Article
- Phenotypic comorbidity network analysis of nasopharyngeal carcinoma: a multicenter study based on hospital discharge records.Frontiers in oncology · 2026Article
- Cancer stage at diagnosis by duration of pre-existing chronic analgesic use and anxiety or depression.Nature communications · 2025Article
- Diagnostic testing patterns for lung cancer-related symptoms in primary care: a retrospective cohort study.BMJ open respiratory research · 2025Article
- Effects of the COVID-19 pandemic and 'Find Cancer Early' campaign on cancer symptom knowledge in regional Western Australia.Journal of public health (Oxford, England) · 2025Article
- Article
- Effects of a Complex Care Model for Patients with Multimorbidity in Lithuania: Results from an Implementation Study.Healthcare (Basel, Switzerland) · 2025Article
- A machine learning tool for identifying metastatic colorectal cancer in primary care.Scandinavian journal of primary health care · 2025Article
48 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
An earlier diagnosis is a key strategy for improving the outcomes of patients with cancer. However, achieving this goal can be challenging, particularly for the growing number of people with one or more chronic conditions (comorbidity/multimorbidity) at the time of diagnosis. Pre-existing chronic diseases might affect patient participation in cancer screening, help-seeking for new and/or changing symptoms and clinicians' decision-making on the use of diagnostic investigations. Evidence suggests, for example, that pre-existing pulmonary, cardiovascular, neurological and psychiatric conditions are all associated with a more advanced stage of cancer at diagnosis. By contrast, hypertension and certain gastrointestinal and musculoskeletal conditions might be associated with a more timely diagnosis. In this Review, we propose a comprehensive framework that encompasses the effects of disease-specific, patient-related and health-care-related factors on the diagnosis of cancer in individuals with pre-existing chronic illnesses. Several previously postulated aetiological mechanisms (including alternative explanations, competing demands and surveillance effects) are integrated with newly identified mechanisms, such as false reassurances, or patient concerns about appearing to be a hypochondriac. By considering specific effects of chronic diseases on diagnostic processes and outcomes, tailored early diagnosis initiatives can be developed to improve the outcomes of the large proportion of patients with cancer who have pre-existing chronic conditions.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.