ArticleNature communications2019
Targeting metabolic driving and intermediate influx in lysine catabolism for high-level glutarate production.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Sustainable production of glutaric acid in microbial cell factories: Current advances and future prospects.Synthetic and systems biotechnology · 2026Review
- Design of the biosensor-dependent coupling system stabilizes the high-synthesis phenotype of cell factory.Nature communications · 2026Article
- Gut microbial metabolites of amino acids in liver diseases.Gut microbes · 2025Review
- A Genetically Encoded Biosensor for Characterizing Transport and Metabolism of Glutarate.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- An innovative strategy for overcoming ultra-high ammonia nitrogen inhibition on anaerobic methanogenesis via stepwise domestication.Microbiome · 2025Article
- Balancing Cell Growth and Product Synthesis for Efficient Microbial Cell Factories.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Production of dicarboxylates from ω-amino acids using a cofactor- and co-substrate-freeEngineering microbiology · 2025Article
- Industrial electrooxidation of glutaraldehyde waste to glutaric acidChemical science · 2025Article
- Microbial Bio-refineries: Engineering Microbes for the Production of Versatile Short-Chain Organic Acids.Indian journal of microbiology · 2025Review
- Hierarchical metabolic engineering for rewiring cellular metabolism.FEMS microbiology reviews · 2025Review
- Microbial mechanisms for higher hydrogen production in anaerobic digestion at constant temperature versus gradient heating.Microbiome · 2024Article
- An integrated cofactor and co-substrate recycling pathway for the biosynthesis of 1,5-pentanediol.Microbial cell factories · 2024Article
- Systems engineering of Escherichia coli for high-level glutarate production from glucose.Nature communications · 2024Article
- TranSyT, an innovative framework for identifying transport systems.Bioinformatics (Oxford, England) · 2023Article
- Efficient bio-production of glutaric acid by a metabolically engineered Escherichia coli LQ-1 based on a novel nitrogen source feeding strategy.Bioprocess and biosystems engineering · 2023Article
- Rethinking Biosynthesis of Aclacinomycin A.Molecules (Basel, Switzerland) · 2023Review
- De novo biosynthesis of α-aminoadipate via multi-strategy metabolic engineering in Escherichia coli.MicrobiologyOpen · 2022Article
- Review
- Article
- Engineering the Cad pathway in Escherichia coli to produce glutarate from L-lysine.Applied microbiology and biotechnology · 2021Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Various biosynthetic pathways have been designed to explore sustainable production of glutarate, an attractive C5 building block of polyesters and polyamides. However, its efficient production has not been achieved in Escherichia coli. Here, we use E. coli native lysine catabolic machinery for glutarate biosynthesis. This endogenous genes-only design can generate strong metabolic driving force to maximize carbon flux toward glutarate biosynthesis by replenishing glutamate and NAD(P)H for lysine biosynthesis, releasing lysine feedback inhibition, and boosting oxaloacetate supply. We use native transporters to overcome extracellular accumulation of cadaverine and 5-aminovalerate. With these efforts, both high titer (54.5 g L
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