ArticleNature communications2019
The histone methyltransferase Setd2 is indispensable for V(D)J recombination.
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Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
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Who cites it
29 citing papers in PubMed, 50 citations in OpenAlex.
- Aberrant Kupffer-like differentiation of hematopoietic stem cell is critical for the MDS pathogenesis in Setd2-deficient mice.Cell death and differentiation · 2026Article
- Ribosome Homeostasis Regulated by SETD2 Preserves Intestinal Epithelial Barrier.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Clinical immunology in chromatinopathies: a scoping review.Frontiers in immunology · 2026Article
- Setd2 ensures the establishment of a precise basal inflammatory state within murine hematopoietic stem/progenitor cells.Cell death & disease · 2025Article
- Emerging role of SETD2 in the development and function of immune cells.Genes & diseases · 2025Review
- Regulatory T cells in homeostasis and disease: molecular mechanisms and therapeutic potential.Signal transduction and targeted therapy · 2025Review
- Role of Histone H3 Lysine 4 Methylation in Chromatin Biology.Molecules (Basel, Switzerland) · 2025Review
- Co-operative epigenetic remodelling by Setd2 deficiency and Kras mutation drives juvenile myelomonocytic leukaemia development and MEK inhibitor sensitivity.British journal of haematology · 2025Article
- ATF7IP/SETDB1-mediated epigenetic programming regulates thymic homing and T lymphopoiesis of hematopoietic progenitors during embryogenesis.Nature communications · 2025Article
- T-cell Receptor Repertoire Analysis in the Context of Transarterial Chemoembolization Synergy with Systemic Therapy for Hepatocellular Carcinoma.Journal of clinical and translational hepatology · 2025Review
- The fall of the genome protectors triad: PBRM1, SETD2, and BAP1's impact on metabolism and immunity in clear cell renal cell carcinoma.Frontiers in cell and developmental biology · 2025Review
- Tumor Cell-Intrinsic SETD2 Deficiency Reprograms Neutrophils to Foster Immune Escape in Pancreatic Tumorigenesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Clinical and histopathologic characterization of SETD2-mutated colorectal cancer.Human pathology · 2023Article
- Decorating chromatin for enhanced genome editing using CRISPR-Cas9.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Setd2 supports GATA3Nature communications · 2022Article
- SETD2 Haploinsufficiency Enhances Germinal Center-Associated AICDA Somatic Hypermutation to Drive B-cell Lymphomagenesis.Cancer discovery · 2022Article
- Shared Mechanisms for Mutually Exclusive Expression and Antigenic Variation by Protozoan Parasites.Frontiers in cell and developmental biology · 2022Review
- Epigenetic modulation of antitumor immunity for improved cancer immunotherapy.Molecular cancer · 2021Review
- SETD2 epidermal deficiency promotes cutaneous wound healing via activation of AKT/mTOR Signalling.Cell proliferation · 2021Article
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Authors and funding
19 authors at 2 institutions in 1 country.
Zhongzhong JiState Key Laboratory of Oncogenes and Related Genes, Renji-Med-X Clinical Stem Cell Research Center, and Department of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.ORCID http://orcid.org/0000-0003-0562-2477
Yaru ShengState Key Laboratory of Oncogenes and Related Genes, Renji-Med-X Clinical Stem Cell Research Center, and Department of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
Juju MiaoState Key Laboratory of Oncogenes and Related Genes, Renji-Med-X Clinical Stem Cell Research Center, and Department of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
Xiaoxia LiState Key Laboratory of Oncogenes and Related Genes, Renji-Med-X Clinical Stem Cell Research Center, and Department of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
Huifang ZhaoState Key Laboratory of Oncogenes and Related Genes, Renji-Med-X Clinical Stem Cell Research Center, and Department of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
Jinming WangState Key Laboratory of Oncogenes and Related Genes, Renji-Med-X Clinical Stem Cell Research Center, and Department of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
Chaping ChengState Key Laboratory of Oncogenes and Related Genes, Renji-Med-X Clinical Stem Cell Research Center, and Department of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
Xue WangState Key Laboratory of Oncogenes and Related Genes, Renji-Med-X Clinical Stem Cell Research Center, and Department of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
Kaiyuan LiuState Key Laboratory of Oncogenes and Related Genes, Renji-Med-X Clinical Stem Cell Research Center, and Department of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
Kai ZhangState Key Laboratory of Oncogenes and Related Genes, Renji-Med-X Clinical Stem Cell Research Center, and Department of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
Longmei XuState Key Laboratory of Oncogenes and Related Genes, Renji-Med-X Clinical Stem Cell Research Center, and Department of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
Jufang YaoState Key Laboratory of Oncogenes and Related Genes, Renji-Med-X Clinical Stem Cell Research Center, and Department of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
Lijing ShenDepartment of Hematology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
Jian HouDepartment of Hematology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
Wenhao ZhouGenetic Center, Children's Hospital of Fudan University, 399 Wanyuan Road, Shanghai, 201102, China.
Jinqiao SunGenetic Center, Children's Hospital of Fudan University, 399 Wanyuan Road, Shanghai, 201102, China. jinqiaosun@fudan.edu.cn.
Li LiState Key Laboratory of Oncogenes and Related Genes, Renji-Med-X Clinical Stem Cell Research Center, and Department of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China. lil@sjtu.edu.cn.ORCID http://orcid.org/0000-0003-2342-3658
Wei-Qiang GaoState Key Laboratory of Oncogenes and Related Genes, Renji-Med-X Clinical Stem Cell Research Center, and Department of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China. gao.weiqiang@sjtu.edu.cn.
Helen He ZhuState Key Laboratory of Oncogenes and Related Genes, Renji-Med-X Clinical Stem Cell Research Center, and Department of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China. zhuhecrane@shsmu.edu.cn.ORCID http://orcid.org/0000-0003-0290-5527
Shanghai Jiao Tong University · CNChildren's Hospital of Fudan University · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
The diverse repertoire of T cell receptors (TCR) and immunoglobulins is generated through the somatic rearrangement of respective V, D and J gene segments, termed V(D)J recombination, during early T or B cell development. However, epigenetic regulation of V(D)J recombination is still not fully understood. Here we show that the deficiency of Setd2, a histone methyltransferase that catalyzes lysine 36 trimethylation on histone 3 (H3K36me3) in mice, causes a severe developmental block of thymocytes at the CD4
Indexed as
V(D)J RecombinationAmino Acid MotifsAnimalsB-LymphocytesCell DifferentiationChild, PreschoolEpigenesis, GeneticHistone-Lysine N-MethyltransferaseHistonesHumansInfantLysineMaleMethylationMiceMice, Inbred C57BLHistone-Lysine N-MethyltransferaseHistonesLysineReceptors, Antigen, T-Cell, alpha-betaSETD2 protein, humanSETD2 protein, mouse
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