ArticleCancer discovery2019
The AMPK-Related Kinases SIK1 and SIK3 Mediate Key Tumor-Suppressive Effects of LKB1 in NSCLC.
Open access · greenAbstract read
In one paragraph
Article in Cancer discovery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed, 1 pooled it
11.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
94 citing papers in PubMed, 1 synthesis or guideline pooled it, 158 citations in OpenAlex.
- Pooled it
- Clinical Outcomes Associated with Single STK11 Mutations and Those Co-occurring with KEAP1 and KRAS Mutations in Metastatic Non-Small Cell Lung Cancer.Advances in therapy · 2026Article
- Molecular insights and therapeutic implications for the tumor suppressor role of LKB1 in non-small cell lung cancer.Cancer letters · 2026Review
- Targeting LKB1-inactivated lung cancers with a stapled peptide inhibitor of the CRTC-CREB pathway.Molecular therapy. Oncology · 2026Article
- SMARCA4, STK11, and KEAP1 co-inactivation associates with poor prognosis and upregulation of the TGF-β pathway in lung adenocarcinoma.Translational oncology · 2026Article
- Temporal control of sgRNA library activation unlocks large-scale in vivo CRISPR screens.Cell reports methods · 2026Article
- Tumor-Derived Complement C3 Overexpression in STK11-Mutant Lung Adenocarcinoma Drives Tumor Growth and Immune Checkpoint Inhibitor Resistance.Cancer immunology research · 2026Article
- LIF-Induced Tumor Plasticity Establishes an Immunosuppressive Myeloid Niche in LKB1-Mutant Lung Cancer.Cancer discovery · 2026Article
- Liver Kinase B1 in CD11cAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Targeting CRTC2 reversesProceedings of the National Academy of Sciences of the United States of America · 2026Article
- The Role of Protein Kinases in the Management of Oncological Diseases by Acting on Ferroptotic Pathways.International journal of molecular sciences · 2026Review
- LKB1 promotes lung adenocarcinoma cell senescence by suppressing the O-GlcNAc glycosylation-mediated activation of telomerase.Frontiers in pharmacology · 2026Article
- Abnormal levels of miRNA in pancreatic cancer are linked to tumor progression by regulating the translation of tumor-associated mRNA.Annals of medicine · 2025Review
- Enhanced Selenium Supplement Extends Lifespan and Delays Multi-Organs Aging by Regulating the Sik1 Pathway Through Maintaining Calcium Homeostasis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Targeting LKB1/STK11-mutant cancer: distinct metabolism, microenvironment, and therapeutic resistance.Trends in pharmacological sciences · 2025Review
- Orthotopically Implanted Murine Lung Adenocarcinoma Cell Lines for Preclinical Investigations.Cancers · 2025Review
- Liposome-encapsulated AICAR hydrogel regulates macrophage metabolic reprogramming via SIK1 activation to alleviate osteoarthritis.Journal of nanobiotechnology · 2025Article
- SCD1 Inhibition Blocks the AKT-NRF2-SLC7A11 Pathway to Induce Lipid Metabolism Remodeling and Ferroptosis Priming in Lung Adenocarcinoma.Cancer research · 2025Article
- IL-17 links the tumor suppressor LKB1 to gastrointestinal inflammation and polyposis.Science advances · 2025Article
- KRAS mutated NSCLC: past, present, and future directions in a rapidly evolving landscape.The oncologist · 2025Review
34 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 3 institutions in 2 countries.
Pablo E HollsteinMolecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California.
Lillian J EichnerMolecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California.
Sonja N BrunMolecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California.
Anwesh KamireddyMolecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California.
Robert U SvenssonMolecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California.
Liliana I VeraMolecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California.
Debbie S RossMolecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California.
T J RymoffMolecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California.
Amanda HutchinsMolecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California.
Hector M GalvezMolecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California.ORCID 0000-0001-9331-6116
April E WilliamsRazavi Newman Integrative Genomics and Bioinformatics Core, The Salk Institute for Biological Studies, La Jolla, California.ORCID 0000-0001-9281-8528
Maxim N ShokhirevRazavi Newman Integrative Genomics and Bioinformatics Core, The Salk Institute for Biological Studies, La Jolla, California.ORCID 0000-0002-8379-8657
Robert A ScreatonSunnybrook Research Institute and Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada.
Rebecca BerdeauxDepartment of Integrative Biology and Pharmacology, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, Texas.ORCID 0000-0002-9929-1711
Reuben J ShawMolecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California. shaw@salk.edu.
Salk Institute for Biological Studies · USSunnybrook Health Science Centre · CAThe University of Texas Health Science Center · US
Funding
Viral Vector Core (VVC)P30CA014195 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Ye Zheng · 1985 to 2026
$82.8MTuberous Sclerosis-Pathway and PathogenesisP01CA120964 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI David J. Kwiatkowski · 2007 to 2026
$35.9MDecoding And Targeting The LKB1-AMPK Signaling Pathway In CancerR35CA220538 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Reuben Shaw · 2017 to 2026
$11.3MSalk Institute Cancer Training GrantT32CA009370 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Diana Clare Hargreaves, Jan Karlseder · 1986 to 2026
$8.6MMOLECULAR BIOLOGICAL APPROACHES TO ENDOCRINOLOGYT32DK007541 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GAULTON, KYLE JEFFRIE, MAJITHIA, AMIT · 1987 to 2022
$4.5MRegulation of glucose utilization by skeletal muscle SIK1R01DK092590 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BERDEAUX, REBECCA L · 2011 to 2021
$3.3MThe role of SIK1 in myogenic differentiation and skeletal muscle repairR01AR059847 · NIAMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BERDEAUX, REBECCA L · 2011 to 2015
$1.7MDefining the role of Wnt5a in LKB1-deficient non-small cell lung cancer metastasisF32CA206400 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI BRUN, SONJA · 2016 to 2017
$111kNCI NIH HHS F32 CA206400NCI NIH HHS P01 CA120964NCI NIH HHS P30 CA014195NCI NIH HHS R35 CA220538NCI NIH HHS T32 CA009370NIAMS NIH HHS R01 AR059847NIDDK NIH HHS R01 DK092590NIDDK NIH HHS T32 DK007541
Abstract
Mutations in the LKB1 (also known as
Indexed as
A549 CellsAMP-Activated Protein Kinase KinasesAMP-Activated Protein KinasesAnimalsCarcinoma, Non-Small-Cell LungCell Line, TumorCRISPR-Cas SystemsGene EditingGene Expression Regulation, NeoplasticHumansLung NeoplasmsMiceNeoplasm TransplantationProtein KinasesProtein Serine-Threonine KinasesProto-Oncogene Proteins p21(ras)AMP-Activated Protein Kinase KinasesAMP-Activated Protein KinasesHras protein, mouseProtein KinasesProtein Serine-Threonine KinasesProto-Oncogene Proteins p21(ras)SIK1 protein, humanSik1 protein, mouseSIK3 protein, humanSIK3 protein, mouseSTK11 protein, humanStk11 protein, mouse
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.