ArticleThe Journal of experimental medicine2019
CSF-1 controls cerebellar microglia and is required for motor function and social interaction.
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Article in The Journal of experimental medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 130 papers.
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130citing papers in PubMed
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130 citing papers in PubMed, 210 citations in OpenAlex.
- Cytokine circuits in CNS homeostasis and disease.Nature immunology · 2026Review
- Targeting Microglial Transcriptional Reprogramming as a Therapy Strategy for Alzheimer's Disease.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- Plasticity of the infant immune system during the perinatal period.Nature reviews. Immunology · 2026Review
- G protein-coupled receptor 75 mediates depression-like behaviors and HPA axis hyperactivity through an excitatory arcuate-paraventricular nucleus circuit.Acta pharmacologica Sinica · 2026Article
- Human-specific SRGAP2 paralogs synchronize neotenic microglial maturation and synaptic development.Neuron · 2026Article
- Microglial maturation across human and mouse as a reference for interpreting large-animal models of perinatal brain injury.Pediatric research · 2026Review
- CSF1R+ Macrophages and Osteoclasts Are Essential for Limb Bone Development During Embryogenesis.Journal of developmental biology · 2026Article
- CSF1R-related leukoencephalopathy: experimental models and potential for treatment.Disease models & mechanisms · 2026Review
- Microglia and neuroinflammation: function, heterogeneity, and crosstalk.Cellular & molecular immunology · 2026Review
- Interleukin-34-Induced Arg1+ Macrophages Play a Key Role in Breast Cancer Brain Metastasis.Cancer research communications · 2026Article
- Identification of secondary microglial formation centers in the human fetal brain.The Journal of experimental medicine · 2026Article
- Microglial Adaptations to Chronic Nicotine in the Cerebellum: Proteomic Evidence for Neuroimmune Vulnerability.Journal of proteome research · 2026Article
- Oligodendrocyte precursor cells-microglia crosstalk via BMP4 drives microglial neuroprotective response and mitigates Alzheimer's disease.Signal transduction and targeted therapy · 2026Article
- Microglial NCAM1 attenuates ischemic brain injury by inhibiting NF-κB-driven neuroinflammation through IκBα stabilization.Journal of neuroinflammation · 2026Article
- Diversity and immune dynamics of choroid plexus macrophages are shaped by distinct developmental origins.Nature neuroscience · 2026Article
- Microglial colonization of the developing mouse brain is controlled by both microglial and neural CSF-1.The EMBO journal · 2026Article
- "Stand by me": astrocyte-microglia crosstalk in central nervous system development, homeostasis, injury, and disease.Frontiers in network physiology · 2026Review
- IL-34 in neurological homeostasis and its multifaceted roles in central nervous system diseases.Frontiers in immunology · 2026Review
- Dysregulated Microglial Synaptic Engulfment in Diffuse Midline Glioma.bioRxiv : the preprint server for biology · 2025Article
- Microglial Prrc2a regulates microglia-neuron interaction in cerebellum and motor functions in mice.iScience · 2025Article
70 more citing papers are in PubMed but not listed here.
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Authors and funding
31 authors at 6 institutions in 3 countries.
Veronika Kana *Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY.
Fiona A Desland *Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY.
Maria Casanova-AcebesDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY.ORCID 0000-0002-5790-1163
Pinar AyataFishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY.ORCID 0000-0001-7621-832X
Ana BadimonFishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY.ORCID 0000-0002-4900-6804
Elisa NabelFishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY.
Kazuhiko YamamuroFishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY.
Marjolein SneeboerDepartment of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
I-Li TanDevelopmental Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY.
Meghan E FlaniganFishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY.
Samuel A RoseDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY.
Christie ChangDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY.
Andrew LeaderDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY.ORCID 0000-0003-3738-7109
Hortense Le BourhisDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY.
Eric S SweetFishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY.ORCID 0000-0003-3930-7360
Navpreet TungDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY.
Aleksandra WroblewskaDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY.ORCID 0000-0003-2059-6158
Yonit LavinDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY.
Peter SeeSingapore Immunology Network, Agency for Science, Technology, and Research, Singapore.ORCID 0000-0003-4428-7763
Alessia BaccariniDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY.
Florent GinhouxSingapore Immunology Network, Agency for Science, Technology, and Research, Singapore.
Violeta ChituDepartment of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY.ORCID 0000-0001-6641-1564
E Richard StanleyDepartment of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY.ORCID 0000-0002-2910-2065
Scott J RussoFishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY.
Zhenyu YueFishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY.
Brian D BrownDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY.
Alexandra L JoynerDevelopmental Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY.
Lotje D De WitteDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY.
Hirofumi MorishitaFishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY.
Anne SchaeferFishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY.
Miriam MeradDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY miriam.merad@mssm.edu.ORCID 0000-0002-4481-7827
Icahn School of Medicine at Mount Sinai · USAllen Institute for Brain Science · USAgency for Science, Technology and Research · SGAlbert Einstein College of Medicine · USMemorial Sloan Kettering Cancer Center · USUtrecht University · NL
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4MViral Assays CoreU19AI128949 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Donna L. Farber, Peter Alan Sims · 2017 to 2026
$26.4MTranscription Factors in Stimulant and Opioid ActionP01DA047233 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Li Shen · 2019 to 2026
$16.5MTRAINING PROGRAM IN CANCER THERAPYT32CA078207 · NCI · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI James J Manfredi · 1999 to 2026
$11.6MROLE OF PERIPHERAL IMMUNE-DERIVED MMP8 IN STRESS SUSCEPTIBILITYR01MH104559 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SCOTT JAMES RUSSO · 2014 to 2026
$9.2MERK control of Dendritic Cell Differentiation, Homeostasis and DiseaseR01CA154947 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CARL E ALLEN, MIRIAM MERAD · 2011 to 2026
$7.0MMaturation of frontal cortico-thalamic circuitry in control of social behaviorR01MH118297 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Hirofumi Morishita · 2019 to 2026
$4.6MUnderstanding the mechanism of SPl1 dependent Alzheimer disease riskRF1AG054011 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GOATE, ALISON M · 2016 to 2016
$4.2MMechanisms regulating the maturation of prefrontal top-down circuity in control of attentional behaviorR01MH119523 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MORISHITA, HIROFUMI · 2019 to 2023
$3.2MResearch Training in the Neuroscience of AgingT32AG049688 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Joseph Michael Castellano, PATRICK R HOF · 2015 to 2026
$3.0MCognate microglia-neuron interaction and its role in inflammationDP2MH100012 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SCHAEFER, ANNE · 2012 to 2012
$2.5MRegulation of adult visual cortex plasticity by endogenous nicotinic modulatorsR01EY024918 · NEI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MORISHITA, HIROFUMI · 2015 to 2019
$2.5MNCI NIH HHS P30 CA008748NCI NIH HHS R01 CA154947NCI NIH HHS T32 CA078207NEI NIH HHS R01 EY024918NEI NIH HHS R01 EY026053NEI NIH HHS R01 EY031009NEI NIH HHS R21 EY026702NIAID NIH HHS U19 AI128949NIA NIH HHS RF1 AG054011NIA NIH HHS T32 AG049688NIDA NIH HHS P01 DA047233NIMH NIH HHS DP2 MH100012NIMH NIH HHS F30 MH111143NIMH NIH HHS R01 MH104559NIMH NIH HHS R01 MH118297NIMH NIH HHS R01 MH118329NIMH NIH HHS R01 MH119523NIMH NIH HHS R21 MH106919NINDS NIH HHS R01 NS091519NINDS NIH HHS R21 NS105119
Abstract
Microglia, the brain resident macrophages, critically shape forebrain neuronal circuits. However, their precise function in the cerebellum is unknown. Here we show that human and mouse cerebellar microglia express a unique molecular program distinct from forebrain microglia. Cerebellar microglial identity was driven by the CSF-1R ligand CSF-1, independently of the alternate CSF-1R ligand, IL-34. Accordingly, CSF-1 depletion from Nestin
Indexed as
Social BehaviorAnimalsBehavior, AnimalHumansMacrophage Colony-Stimulating FactorMiceMice, TransgenicMicrogliaMotor ActivityPurkinje CellsReceptor, Macrophage Colony-Stimulating FactorSignal TransductionMacrophage Colony-Stimulating FactorReceptor, Macrophage Colony-Stimulating Factor
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