Evidence map›Paper›PMID 31350286›Full record

ArticleDisease models & mechanisms2019

Modelling the MYC-driven normal-to-tumour switch in breast cancer.

Corey Lourenco, Manpreet Kalkat, Kathleen E Houlahan, Jason De Melo, Joseph Longo, Susan J Done, Paul C Boutros, Linda Z Penn

Open access · goldAbstract read
In one paragraph

Article in Disease models & mechanisms, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Beyond the Limit: MYC Mediates Tumor Immune Escape.Pharmaceuticals (Basel, Switzerland) · 2025
    Review
  3. mInternational journal of oral science · 2024
    Article
  4. Article
  5. Article
  6. Article
  7. 3D chromatin remodeling potentiates transcriptional programs driving cell invasion.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  8. Article
  9. Review
  10. Article
  11. Image-Based Analysis of Protein Stability.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2020
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Corey LourencoPrincess Margaret Cancer Centre, University Health Network, 101 College St, Toronto, ON M5G 0A3, Canada.ORCID 0000-0001-9075-7661
Manpreet KalkatPrincess Margaret Cancer Centre, University Health Network, 101 College St, Toronto, ON M5G 0A3, Canada.
Kathleen E HoulahanDepartment of Medical Biophysics, University of Toronto, 101 College Street Suite 15-701, Toronto, ON M5G 1L7, Canada.
Jason De MeloPrincess Margaret Cancer Centre, University Health Network, 101 College St, Toronto, ON M5G 0A3, Canada.
Joseph LongoPrincess Margaret Cancer Centre, University Health Network, 101 College St, Toronto, ON M5G 0A3, Canada.
Susan J DonePrincess Margaret Cancer Centre, University Health Network, 101 College St, Toronto, ON M5G 0A3, Canada.
Paul C BoutrosDepartment of Medical Biophysics, University of Toronto, 101 College Street Suite 15-701, Toronto, ON M5G 1L7, Canada.ORCID 0000-0003-0553-7520
Linda Z PennPrincess Margaret Cancer Centre, University Health Network, 101 College St, Toronto, ON M5G 0A3, Canada lpenn@uhnres.utoronto.ca.ORCID 0000-0001-8133-5459
University Health Network · CAOntario Institute for Cancer Research · CA

Funding

CIHR
6 · The paper itself

Abstract

The potent MYC oncoprotein is deregulated in many human cancers, including breast carcinoma, and is associated with aggressive disease. To understand the mechanisms and vulnerabilities of MYC-driven breast cancer, we have generated an

Indexed as

Genes, mycModels, BiologicalBreastBreast NeoplasmsCell Line, TumorCell Transformation, NeoplasticFemaleGene Expression Regulation, NeoplasticHumansNeoplasm InvasivenessPhosphatidylinositol 3-KinasesSignal TransductionPhosphatidylinositol 3-KinasesBreast cancerCancer modelDriver oncogeneMicroenvironmentMYCPI3K

Identifiers

PMID31350286
PMCPMC6679384
OpenAlexW2966771699

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.