Evidence map›Paper›PMID 31350281›Full record

ArticleScience immunology2019

Alveolar macrophages generate a noncanonical NRF2-driven transcriptional response

Alissa C Rothchild, Gregory S Olson, Johannes Nemeth, Lynn M Amon, Dat Mai, Elizabeth S Gold, Alan H Diercks, Alan Aderem

Open access · greenAbstract read
In one paragraph

Article in Science immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 119 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
119citing papers in PubMed, 1 pooled it
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

119 citing papers in PubMed, 1 synthesis or guideline pooled it, 173 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Microbiology spectrum · 2026
    Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Restricted MHC-II trafficking inbioRxiv : the preprint server for biology · 2026
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Diverse infection models demonstrate robust resistance ofbioRxiv : the preprint server for biology · 2026
    Article
  15. Modulation of Ferroptosis During EarlybioRxiv : the preprint server for biology · 2026
    Article
  16. Article
  17. HowVaccines · 2026
    Review
  18. Article
  19. Article
  20. Article

59 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Alissa C RothchildCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA 98109, USA.ORCID 0000-0001-7484-1193
Gregory S OlsonCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA 98109, USA.ORCID 0000-0001-7181-9636
Johannes NemethCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA 98109, USA.ORCID 0000-0003-0683-456X
Lynn M AmonCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA 98109, USA.ORCID 0000-0002-6420-7698
Dat MaiCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA 98109, USA.ORCID 0000-0002-3781-8151
Elizabeth S GoldCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA 98109, USA.
Alan H DiercksCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA 98109, USA. alan.aderem@seattlechildrens.org alan.diercks@seattlechildrens.org.
Alan AderemCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA 98109, USA. alan.aderem@seattlechildrens.org alan.diercks@seattlechildrens.org.ORCID 0000-0003-4031-5499
Infectious Disease Research Institute · US

Funding

Systems Biology CoreU19AI100627 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI ULEVITCH, RICHARD J · 2012 to 2021
$49.1M
Technology CoreU19AI106761 · NIAID · SEATTLE BIOMEDICAL RESEARCH INSTITUTE · PI SHERMAN, DAVID R, ZAK, DANIEL E · 2013 to 2017
$18.9M
Technology CoreU19AI135976 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI ADEREM, ALAN A · 2018 to 2022
$17.0M
LPS Signaling in Macrophages: The Roll of TollR01AI032972 · NIAID · UNIVERSITY OF WASHINGTON · PI ADEREM, ALAN A · 1992 to 2020
$14.6M
NIAID NIH HHS R01 AI032972NIAID NIH HHS U19 AI100627NIAID NIH HHS U19 AI106761NIAID NIH HHS U19 AI135976
6 · The paper itself

Abstract

Alveolar macrophages (AMs) are the first cells to be infected during

Indexed as

Transcription, GeneticAnimalsFemaleMacrophages, AlveolarMaleMiceMice, Inbred C57BLMice, KnockoutMycobacterium tuberculosisNF-E2-Related Factor 2Tuberculosis, PulmonaryNfe2l2 protein, mouseNF-E2-Related Factor 2

Identifiers

PMID31350281
PMCPMC6910245
OpenAlexW2966718046

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.