Evidence map›Paper›PMID 31350280›Full record

ArticleThe Journal of cell biology2019

CDK2 regulates the NRF1/

Nathan Palmer, S Zakiah A Talib, Chandrahas Koumar Ratnacaram, Diana Low, Xavier Bisteau, Joanna Hui Si Lee, Elisabeth Pfeiffenberger, Heike Wollmann, Joel Heng Loong Tan, Sheena Wee and 5 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of cell biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 18 citations in OpenAlex.

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  12. An N-ethyl-N-Nitrosourea Mutagenesis Screen in Mice Reveals a Mutation inAnimals : an open access journal from MDPI · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Nathan PalmerInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore.
S Zakiah A Talib *Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore.
Chandrahas Koumar Ratnacaram *Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore.
Diana Low *Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore.
Xavier BisteauInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore.ORCID 0000-0002-8896-5098
Joanna Hui Si LeeInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore.
Elisabeth PfeiffenbergerInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore.
Heike WollmannInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore.
Joel Heng Loong TanInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore.
Sheena WeeInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore.
Radoslaw SobotaInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore.ORCID 0000-0002-2455-2526
Jayantha GunaratneInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore.
Daniel M MesserschmidtInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore.
Ernesto GuccioneInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore ernesto.guccione@mssm.edu.
Philipp KaldisInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore 22mtbx29@gmail.com.ORCID 0000-0002-7247-7591
Agency for Science, Technology and Research · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Meiosis generates four genetically distinct haploid gametes over the course of two reductional cell divisions. Meiotic divisions are characterized by the coordinated deposition and removal of various epigenetic marks. Here we propose that nuclear respiratory factor 1 (NRF1) regulates transcription of euchromatic histone methyltransferase 1 (EHMT1) to ensure normal patterns of H3K9 methylation during meiotic prophase I. We demonstrate that cyclin-dependent kinase (CDK2) can bind to the promoters of a number of genes in male germ cells including that of

Indexed as

Gene Expression Regulation, EnzymologicAnimalsCyclin-Dependent Kinase 2Gene DeletionHistone-Lysine N-MethyltransferaseMaleMeiotic Prophase IMiceMice, KnockoutNuclear Respiratory Factor 1SpermatocytesCdk2 protein, mouseCyclin-Dependent Kinase 2GLP protein, mouseHistone-Lysine N-MethyltransferaseNrf1 protein, mouseNuclear Respiratory Factor 1

Identifiers

PMID31350280
PMCPMC6719441
OpenAlexW2966202285

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.