Evidence map›Paper›PMID 31350252›Full record

ArticleBMJ open2019

Subclinical thyroid dysfunction and depressive symptoms: protocol for a systematic review and individual participant data meta-analysis of prospective cohort studies.

Lea Wildisen, Elisavet Moutzouri, Shanthi Beglinger, Lamprini Syrogiannouli, Anne R Cappola, Bjørn O Åsvold, Stephan J L Bakker, Graziano Ceresini, Robin Dullaart, Luigi Ferrucci and 15 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Lea WildisenInstitute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland.ORCID 0000-0003-2097-8674
Elisavet MoutzouriInstitute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland.
Shanthi BeglingerInstitute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland.
Lamprini SyrogiannouliInstitute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland.
Anne R CappolaDepartment of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania, USA.
Bjørn O ÅsvoldDepartment of Public Health and Nursing, K.G. Jebsen Center for Genetic Epidemiology, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
Stephan J L BakkerDepartment of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Graziano CeresiniDepartment of Clinical and Experimental Medicine, Geriatric Endocrine Unit, University Hospital of Parma, Parma, Italy.
Robin DullaartDepartment of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Luigi FerrucciLongitudinal Studies Section, Translational Gerontology Branch, Harbor Hospital, Baltimore, National Institute on Aging NIA-ASTRA Unit, Baltimore, Maryland, USA.
Hans GrabeInstitute for Community Medicine, Clinical-Epidemiological Research, University Medicine Greifswald, Greifswald, Germany.
J Wouter JukemaDepartment of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
Matthias NauckInstitute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.
Stella TrompetSection Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands.
Henry VölzkeInstitute for Community Medicine, Clinical-Epidemiological Research, University Medicine Greifswald, Greifswald, Germany.
Rudi G J WestendorpDepartment of Public Health and Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark.
Jacobijn GusseklooSection Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands.
Robin P PeetersDepartment of Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
Stefan KlöppelUniversity Hospital of Old Age Psychatry, University of Bern, Bern, Switzerland.
Drahomir AujeskyDepartment of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Douglas C BauerDepartments of Medicine and Epidemiology & Biostatistics, University of California, San Francisco, California, USA.
Nicolas RodondiInstitute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland.
Cinzia Del GiovaneInstitute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland.
Martin FellerInstitute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland.
Thyroid Studies Collaboration

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionProspective cohort studies on the association between subclinical thyroid dysfunction and depressive symptoms have yielded conflicting findings, possibly because of differences in age, sex, thyroid-stimulating hormone cut-off levels or degree of baseline depressive symptoms. Analysis of individual participant data (IPD) may help clarify this association. METHODS AND ANALYSIS: We will conduct a systematic review and IPD meta-analysis of prospective studies on the association between subclinical thyroid dysfunction and depressive symptoms. We will identify studies through a systematic search of the literature in the Ovid Medline, Ovid Embase, Cochrane Central Register of Controlled Trials (CENTRAL) and Cumulative Index to Nursing and Allied Health Literature (CINAHL) databases from inception to April 2019 and from the Thyroid Studies Collaboration. We will ask corresponding authors of studies that meet our inclusion criteria to collaborate by providing IPD. Our primary outcome will be depressive symptoms at the first available individual follow-up, measured on a validated scale. We will convert all the scores to the Beck Depression Inventory scale. For each cohort, we will estimate the mean difference of depressive symptoms between participants with subclinical hypothyroidism or hyperthyroidism and control adjusted for depressive symptoms at baseline. Furthermore, we will adjust our multivariable linear regression analyses for age, sex, education and income. We will pool the effect estimates of all studies in a random-effects meta-analysis. Heterogeneity will be assessed by I ETHICS AND DISSEMINATION: Formal ethical approval is not required as primary data will not be collected. Our findings will have considerable implications for patient care. We will seek to publish this systematic review and IPD meta-analysis in a high-impact clinical journal. PROSPERO REGISTRATION NUMBER: CRD42018091627.

Indexed as

Cohort StudiesDepressionHumansMeta-Analysis as TopicPsychiatric Status Rating ScalesResearch DesignSystematic Reviews as TopicThyroid DiseasesThyroid Function TestsThyroid HormonesThyrotropinThyroid HormonesThyrotropindepressive symptomsindividual participant data (IPD) meta-analysissubclinical hyperthyroidismsubclinical hypothyroidismsubclinical thyroid dysfunctionsystematic review

Identifiers

PMID31350252
PMCPMC6661665

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.