Evidence map›Paper›PMID 31350118›Full record

ArticleMolecular cell2019

Time-Resolved Small RNA Sequencing Unravels the Molecular Principles of MicroRNA Homeostasis.

Brian Reichholf, Veronika A Herzog, Nina Fasching, Raphael A Manzenreither, Ivica Sowemimo, Stefan L Ameres

Open access · bronzeAbstract read
In one paragraph

Article in Molecular cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 117 papers.

0numbers the graph read from it
0cells of the map it votes in
117citing papers in PubMed
6.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

117 citing papers in PubMed, 169 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Genes & development · 2026
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

57 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Brian ReichholfInstitute of Molecular Biotechnology (IMBA), Vienna BioCenter (VBC), 1030 Vienna, Austria.
Veronika A HerzogInstitute of Molecular Biotechnology (IMBA), Vienna BioCenter (VBC), 1030 Vienna, Austria.
Nina FaschingInstitute of Molecular Biotechnology (IMBA), Vienna BioCenter (VBC), 1030 Vienna, Austria.
Raphael A ManzenreitherInstitute of Molecular Biotechnology (IMBA), Vienna BioCenter (VBC), 1030 Vienna, Austria.
Ivica SowemimoInstitute of Molecular Biotechnology (IMBA), Vienna BioCenter (VBC), 1030 Vienna, Austria.
Stefan L AmeresInstitute of Molecular Biotechnology (IMBA), Vienna BioCenter (VBC), 1030 Vienna, Austria. Electronic address: stefan.ameres@imba.oeaw.ac.at.
Institute of Molecular Biotechnology · AT

Funding

Austrian Science Fund FWF F 4322Austrian Science Fund FWF W 1207Austrian Science Fund FWF Y 733European Research Council 338252
6 · The paper itself

Abstract

Argonaute-bound microRNAs silence mRNA expression in a dynamic and regulated manner to control organismal development, physiology, and disease. We employed metabolic small RNA sequencing for a comprehensive view on intracellular microRNA kinetics in Drosophila. Based on absolute rate of biogenesis and decay, microRNAs rank among the fastest produced and longest-lived cellular transcripts, disposing up to 10

Indexed as

Sequence Analysis, RNAAnimalsArgonaute ProteinsCell LineDrosophila melanogasterDrosophila ProteinsHomeostasisMicroRNAsAGO1 protein, DrosophilaArgonaute ProteinsDrosophila ProteinsMicroRNAsArgonautemetabolic RNA labelingmicroRNAspost-transcriptional gene regulationRNA expression dynamicsRNA metabolismsmall RNA homeostasissmall RNA silencingtime-resolved RNA sequencing

Identifiers

PMID31350118
PMCPMC6713562
OpenAlexW2962852416

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.