Evidence map›Paper›PMID 31349923›Full record

ArticleTrends in endocrinology and metabolism: TEM2019

Antagonism between Antiviral Signaling and Glycolysis.

Anoop Singh Chauhan, Li Zhuang, Boyi Gan

Open access · greenAbstract readComment
In one paragraph

Article in Trends in endocrinology and metabolism: TEM, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Lactate and lactylation in tumor immunity.Frontiers of medicine · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. PTSD as an Endothelial Disease: Insights From COVID-19.Frontiers in cellular neuroscience · 2021
    Review
  10. Article
  11. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 2 countries.

Anoop Singh ChauhanDepartment of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham B17 2TT, UK.
Li ZhuangDepartment of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Boyi GanDepartment of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: bgan@mdanderson.org.
The University of Texas MD Anderson Cancer Center · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
Studying metabolic stress signaling in renal cancerR01CA181196 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI GAN, BOYI · 2014 to 2024
$3.4M
NCI NIH HHS P30 CA016672NCI NIH HHS R01 CA181196
6 · The paper itself

Abstract

RIG-I-like receptor (RLR)-mediated interferon production is critical for antiviral responses. A recent study (Zhang et al., Cell, 2019) uncovered a reciprocal inhibition between RLR signaling and glycolysis: lactate produced by glycolysis inhibits RLR signaling by binding to RLR signaling component mitochondrial antiviral-signaling (MAVS), whereas RLR activation suppresses glycolysis through inhibiting glycolysis enzyme hexokinase.

Indexed as

Antiviral AgentsGlycolysisAdaptor Proteins, Signal TransducingLactic AcidSignal TransductionAdaptor Proteins, Signal TransducingAntiviral AgentsLactic AcidglycolysislactateLDHAMAVSRLR signaling

Identifiers

PMID31349923
PMCPMC7944876
OpenAlexW2963522125

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.