ArticleBMC complementary and alternative medicine2019
Efficacy and safety of Curcuma longa essential oil to inactivate hydatid cyst protoscoleces.
Article in BMC complementary and alternative medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Curcumin ((1E,6E)-1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) Induces Apoptosis-like Death inPathogens (Basel, Switzerland) · 2026Article
- High efficacy of camphene and metronidazole combination therapy againstParasite epidemiology and control · 2025Article
- Therapeutic Effects of Green Synthesized Copper Nanoparticles Against Hydatid Disease Through Inhibiting Inflammation, Oxidative Stress, and Apoptosis.Acta parasitologica · 2025Article
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- Antileishmanial and synergic effects of Rhanterium epapposum essential oil and its main compounds alone and combined with glucantime against Leishmania major infection.International journal for parasitology. Drugs and drug resistance · 2024Article
- High potency of linalool-zinc oxide nanocomposite as a new agent for cystic echinococcosis treatment.Antimicrobial agents and chemotherapy · 2024Article
- Ovicidal activity and cytotoxicity of ethanolic extract of turmeric (Open veterinary journal · 2024Article
- Therapeutic effect of curcumin nanoemulsion on cystic echinococcosis in BALB/c mice: a computerized tomography (CT) scan and histopathologic study evaluation.BMC complementary medicine and therapies · 2024Article
- Immunomodulatory, Antioxidant, and Anti-Inflammatory Activities of Green Synthesized Copper Nanoparticles for Treatment of ChronicPharmaceuticals (Basel, Switzerland) · 2023Article
- Green Synthesis, Characterization, and Antiparasitic Effects of Gold Nanoparticles againstTropical medicine and infectious disease · 2023Article
- Eugenol Essential Oil and Nanoemulsion as Antihydatic Agents with Antifibrotic and Immunomodulatory Effects in Cystic Echinococcosis.Tropical medicine and infectious disease · 2023Article
- Protoscolicidal effects of curcumin nanoemulsion against protoscoleces of Echinococcus granulosus.BMC complementary medicine and therapies · 2023Article
- The role ofFrontiers in cellular and infection microbiology · 2023Article
- Targeted Drug Delivery Systems for Curcumin in Breast Cancer Therapy.International journal of nanomedicine · 2023Review
- Essential Oils as Novel Anthelmintic Drug Candidates.Molecules (Basel, Switzerland) · 2022Review
- Pharmacological Profile, Bioactivities, and Safety of Turmeric Oil.Molecules (Basel, Switzerland) · 2022Review
- Herbal Medicines against Hydatid Disease: A Systematic Review (2000-2021).Life (Basel, Switzerland) · 2022Review
- Antiparasitic effects ofSaudi journal of biological sciences · 2022Article
- Nano amphotericin B: a good anti-leishmanial drug with effect on cathelicidin gene expression.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2021Article
- Scolicidal effects ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2021Article
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8 authors.
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Abstract
backgroundOne of the most important ways to cure hydatid cysts is surgery. Today, available chemical drugs have shown severe complications during hydatid cyst surgery. Here we investigated theefficacy and safety of Curcuma longa (C. longa) essential oil (CLEO) against hydatid cysts protoscoleces.
methodsHere, the collected protoscoleces from fertile hydatid cysts were exposed to different concentrations of the CLEO (50-200 μl/mL) for 5-30 min in vitro and ex vivo. In addition, male NIH mice (48 mice) were applied to examine the safety of CLEO.
resultsAll protoscoleces were completely killed in 5th min of treatment to the doses of 200 μl /mL of CLEO. On the other hand, in the 10th min of treatment, CLEO entirely killed 100% of protoscoleces at the dose of 100 μL/mL. Other doses of CLEO, but, revealed a postponed activity. Although CLEO at the doses of 50, and 100 μL/mL exhibited no similar effect in the ex vivo analysis; but, at the dose of 200 μL/mL and an exposure time of 5 min, approximately 100% of protoscoleces were destroyed into the cyst. We found that after intra-peritoneal injection of the CLEO for 14 days, although blood and biochemical parameters were changed; but there was no significant difference in comparison with the control group (p > 0.05).
conclusionThis research demonstrated that C. longa revealed the promising scolicidal effects against protoscoleces in vitro and in vivo, of course, after additional tests; it might be considered as an herbal scolicidal drug in order to decrease the threat of discharge of protoscoleces through hydatid cyst surgery. Nevertheless, supplementary studies will be desired to prove the current findings by examination the essential oil in a clinical setting.
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