Evidence map›Paper›PMID 31349818›Full record

Observational studyBMC infectious diseases2019

Clinical and microbiological characteristics and outcomes of community-acquired sepsis among adults: a single center, 1-year retrospective observational cohort study from Hungary.

Balint Gergely Szabo, Rebeka Kiss, Katalin Szidonia Lenart, Bence Marosi, Eszter Vad, Botond Lakatos, Eszter Ostorhazi

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Observational
  3. Article
  4. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Balint Gergely SzaboSemmelweis University, School of PhD Studies, H-1085 Ulloi ut 26., Budapest, Hungary. szabo.balint.gergely@gmail.com.
Rebeka KissDepartment of Infectious Diseases, Markhot Ferenc Teaching Hospital, H-3300 Szechenyi utca 27-29., Eger, Hungary.
Katalin Szidonia LenartDepartment of Infectious Diseases, South Pest Central Hospital, National Institute of Hematology and Infectious Diseases, Saint Ladislaus Campus, H-1097 Albert Florian ut 5-7., Budapest, Hungary.
Bence MarosiFaculty of Medicine, Students' Scientific Association, Semmelweis University, H-1085 Ulloi ut 26., Budapest, Hungary.
Eszter VadSemmelweis University, School of PhD Studies, H-1085 Ulloi ut 26., Budapest, Hungary.
Botond LakatosDepartment of Infectious Diseases, South Pest Central Hospital, National Institute of Hematology and Infectious Diseases, Saint Ladislaus Campus, H-1097 Albert Florian ut 5-7., Budapest, Hungary.
Eszter OstorhaziSemmelweis University, Institute of Medical Microbiology, H-1098 Nagyvarad ter 4., Budapest, Hungary.ORCID http://orcid.org/0000-0002-9459-7316

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCommunity-acquired sepsis is a life-threatening systemic reaction, which starts within ≤72 h of hospital admittance in an infected patient without recent exposure to healthcare risks. Our aim was to evaluate the characteristics and the outcomes concerning community-acquired sepsis among patients admitted to a Hungarian high-influx national medical center.

methodsA retrospective, observational cohort study of consecutive adult patients hospitalized with community-acquired sepsis during a 1-year period was executed. Clinical and microbiological data were collected, patients with pre-defined healthcare associations were excluded. Sepsis definitions and severity were given according to ACCP/SCCM criteria. The primary outcome was in-hospital all-cause mortality. Secondary outcomes were intensive care unit (ICU) admittance, length-of-stay (LOS), source control and bacteraemia rates. Statistical differences were explored with classical comparison tests, predictors of in-hospital all-cause mortality were modelled by multivariate logistic regression.

results214 patients (median age 60.0 ± 33.1 years, 57% female, median Charlson score 4.0 ± 5.0) were included, 32.7% of them (70/214) had severe sepsis, and 28.5% (61/214) had septic shock. Prevalent sources of infections were genitourinary (53/214, 24.8%) and abdominal (52/214, 24.3%). The causative organisms were dominantly E. coli (60/214, 28.0%), S. pneumoniae (18/214, 8.4%) and S. aureus (14/214, 6.5%), and bacteraemia was documented in 50.9% of the cases (109/214). In-hospital mortality was high (30/214, 14.0%), and independently associated with shock, absence of fever, male gender and the need for ICU admittance, but source control and de-escalation of empirical antimicrobial therapy were protective. ICU admittance was 27.1% (58/214), source control was achieved in 18.2% (39/214). Median LOS was 10.0 ± 8.0, ICU LOS was 8.0 ± 10.8 days.

conclusionsCommunity-acquired sepsis poses a significant burden of disease with characteristic causative agents and sources. Patients at a higher risk for poor outcomes might be identified earlier by the contributing factors shown above.

Indexed as

AdultAgedAged, 80 and overAnti-Bacterial AgentsCohort StudiesCommunity-Acquired InfectionsEscherichia coliFemaleHospitalizationHospital MortalityHumansHungaryIntensive Care UnitsLength of StayMaleMiddle AgedAnti-Bacterial AgentsCommunity-acquiredInfectionMortalitySepsisSeptic shockSIRS

Identifiers

PMID31349818
PMCPMC6659200

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.