Evidence map›Paper›PMID 31349784›Full record

ArticleBMC evolutionary biology2019

The genome of the live-bearing fish Heterandria formosa implicates a role of conserved vertebrate genes in the evolution of placental fish.

Henri van Kruistum, Joost van den Heuvel, Joseph Travis, Ken Kraaijeveld, Bas J Zwaan, Martien A M Groenen, Hendrik-Jan Megens, Bart J A Pollux

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC evolutionary biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Embryonic specializations for vertebrate placentation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022
    Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Henri van KruistumAnimal Breeding and Genomics Group, Wageningen University, Wageningen, The Netherlands. henri.vankruistum@wur.nl.ORCID 0000-0002-5672-9760
Joost van den HeuvelPlant Sciences Group, Laboratory of Genetics, Wageningen University, Wageningen, The Netherlands.
Joseph TravisDepartment of Biological Science, Florida State University, Tallahassee, USA.
Ken KraaijeveldInstitute for Biodiversity and Ecosystem Dynamics, University of Amsterdam, Amsterdam, The Netherlands.
Bas J ZwaanPlant Sciences Group, Laboratory of Genetics, Wageningen University, Wageningen, The Netherlands.
Martien A M GroenenAnimal Breeding and Genomics Group, Wageningen University, Wageningen, The Netherlands.
Hendrik-Jan MegensAnimal Breeding and Genomics Group, Wageningen University, Wageningen, The Netherlands.
Bart J A PolluxExperimental Zoology Group, Wageningen University, Wageningen, The Netherlands.
Wageningen University & Research · NLFlorida State University · USLeiden University Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe evolution of complex organs is thought to occur via a stepwise process, each subsequent step increasing the organ's complexity by a tiny amount. This evolutionary process can be studied by comparing closely related species that vary in the presence or absence of their organs. This is the case for the placenta in the live-bearing fish family Poeciliidae, as members of this family vary markedly in their ability to supply nutrients to their offspring via a placenta. Here, we investigate the genomic basis underlying this phenotypic variation in Heterandria formosa, a poeciliid fish with a highly complex placenta. We compare this genome to three published reference genomes of non-placental poeciliid fish to gain insight in which genes may have played a role in the evolution of the placenta in the Poeciliidae.

resultsWe sequenced the genome of H. formosa, providing the first whole genome sequence for a placental poeciliid. We looked for signatures of adaptive evolution by comparing its gene sequences to those of three non-placental live-bearing relatives. Using comparative evolutionary analyses, we found 17 genes that were positively selected exclusively in H. formosa, as well as five gene duplications exclusive to H. formosa. Eight of the genes evolving under positive selection in H. formosa have a placental function in mammals, most notably endometrial tissue remodelling or endometrial cell proliferation.

conclusionsOur results show that a substantial portion of positively selected genes have a function that correlates well with the morphological changes that form the placenta of H. formosa, compared to the corresponding tissue in non-placental poeciliids. These functions are mainly endometrial tissue remodelling and endometrial cell proliferation. Therefore, we hypothesize that natural selection acting on genes involved in these functions plays a key role in the evolution of the placenta in H. formosa.

Indexed as

Biological EvolutionConserved SequenceGenomeAnimalsCyprinodontiformesFemaleGene DuplicationPlacentaPregnancySelection, GeneticWhole Genome SequencingGene duplicationHeterandria formosaMatrotrophyMolecular evolutionPlacentaPoeciliidaePositive selectionWhole genome sequencing

Identifiers

PMID31349784
PMCPMC6660938
OpenAlexW2965512160

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.