Evidence map›Paper›PMID 31349760›Full record

ArticleCell cycle (Georgetown, Tex.)2019

The NEDD8-activating enzyme inhibitor MLN4924 induces DNA damage in Ph+ leukemia and sensitizes for ABL kinase inhibitors.

Mahnoush Bahjat, Guus de Wilde, Tijmen van Dam, Chiel Maas, Timon Bloedjes, Richard J Bende, Carel J M van Noesel, Dieuwertje M Luijks, Eric Eldering, Marie José Kersten and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell cycle (Georgetown, Tex.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Mahnoush BahjatDepartment of Pathology, Amsterdam University Medical Centers, location AMC, University of Amsterdam , Amsterdam , The Netherlands.
Guus de WildeDepartment of Pathology, Amsterdam University Medical Centers, location AMC, University of Amsterdam , Amsterdam , The Netherlands.ORCID 0000-0002-0928-9977
Tijmen van DamDepartment of Pathology, Amsterdam University Medical Centers, location AMC, University of Amsterdam , Amsterdam , The Netherlands.
Chiel MaasDepartment of Pathology, Amsterdam University Medical Centers, location AMC, University of Amsterdam , Amsterdam , The Netherlands.
Timon BloedjesDepartment of Pathology, Amsterdam University Medical Centers, location AMC, University of Amsterdam , Amsterdam , The Netherlands.
Richard J BendeDepartment of Pathology, Amsterdam University Medical Centers, location AMC, University of Amsterdam , Amsterdam , The Netherlands.ORCID 0000-0002-5173-3138
Carel J M van NoeselDepartment of Pathology, Amsterdam University Medical Centers, location AMC, University of Amsterdam , Amsterdam , The Netherlands.ORCID 0000-0001-7907-7390
Dieuwertje M LuijksLymphoma and Myeloma Center Amsterdam (LYMMCARE) , Amsterdam , The Netherlands.
Eric ElderingLymphoma and Myeloma Center Amsterdam (LYMMCARE) , Amsterdam , The Netherlands.
Marie José KerstenLymphoma and Myeloma Center Amsterdam (LYMMCARE) , Amsterdam , The Netherlands.
Jeroen E J GuikemaDepartment of Pathology, Amsterdam University Medical Centers, location AMC, University of Amsterdam , Amsterdam , The Netherlands.ORCID 0000-0001-6894-3441
Amsterdam University Medical Centers · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The

Indexed as

ApoptosisCell Line, TumorCyclopentanesDNA DamageDrug Resistance, NeoplasmDrug SynergismDrug Therapy, CombinationFusion Proteins, bcr-ablHumansImatinib MesylateLeukemia, Myelogenous, Chronic, BCR-ABL PositiveMyeloid Cell Leukemia Sequence 1 ProteinProtein Kinase InhibitorsProto-Oncogene Proteins c-bcl-2PyrimidinesSignal TransductionBCR-ABL1 fusion protein, humanCyclopentanesFusion Proteins, bcr-ablImatinib MesylateMCL1 protein, humanMyeloid Cell Leukemia Sequence 1 ProteinNAE protein, humanpevonedistatPMAIP1 protein, humanProtein Kinase InhibitorsProto-Oncogene Proteins c-bcl-2PyrimidinesUbiquitin-Activating EnzymesDNA damageNeddylationPh+ leukemia

Identifiers

PMID31349760
PMCPMC6738521
OpenAlexW2965231573

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.