Evidence map›Paper›PMID 31349736›Full record

ArticleCells2019

Rifampicin and Its Derivative Rifampicin Quinone Reduce Microglial Inflammatory Responses and Neurodegeneration Induced In Vitro by α-Synuclein Fibrillary Aggregates.

Leonardo Acuña, Sabah Hamadat, Natalia S Corbalán, Florencia González-Lizárraga, Mauricio Dos-Santos-Pereira, Jérémy Rocca, Julia Sepúlveda Díaz, Elaine Del-Bel, Dulce Papy-García, Rosana N Chehín and 2 more

Open access · goldAbstract read
In one paragraph

Article in Cells, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 58 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Mathematical Modeling of Neuroinflammation in Neurodegenerative Diseases.CPT: pharmacometrics & systems pharmacology · 2025
    Review
  5. Review
  6. Review
  7. Quinones as Neuroprotective Agents.Antioxidants (Basel, Switzerland) · 2023
    Review
  8. Role of neuroinflammation in neurodegeneration development.Signal transduction and targeted therapy · 2023
    Review
  9. Review
  10. Article
  11. Alpha Synuclein: Neurodegeneration and Inflammation.International journal of molecular sciences · 2023
    Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Frontiers in neuroscience · 2022
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Leonardo AcuñaInstitut du Cerveau et de la Moelle épinière (ICM), Inserm U 1127, CNRS UMR 7225, Sorbonne Université, F-75013 Paris, France.
Sabah HamadatInstitut du Cerveau et de la Moelle épinière (ICM), Inserm U 1127, CNRS UMR 7225, Sorbonne Université, F-75013 Paris, France.
Natalia S CorbalánLaboratoire Croissance, Régénération, Réparation et Régénération Tissulaires (CRRET)/ EAC CNRS 7149, Université Paris Est Créteil, Université Paris Est, 94010 Créteil, France.
Florencia González-LizárragaInstituto de Medicina Molecular y Celular Aplicada (IMMCA) CONICET/UNT and SIPROSA, Tucumán T4000ILI, Argentina.
Mauricio Dos-Santos-PereiraInstitut du Cerveau et de la Moelle épinière (ICM), Inserm U 1127, CNRS UMR 7225, Sorbonne Université, F-75013 Paris, France.
Jérémy RoccaInstitut du Cerveau et de la Moelle épinière (ICM), Inserm U 1127, CNRS UMR 7225, Sorbonne Université, F-75013 Paris, France.
Julia Sepúlveda DíazInstitut du Cerveau et de la Moelle épinière (ICM), Inserm U 1127, CNRS UMR 7225, Sorbonne Université, F-75013 Paris, France.
Elaine Del-BelFaculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil.
Dulce Papy-GarcíaLaboratoire Croissance, Régénération, Réparation et Régénération Tissulaires (CRRET)/ EAC CNRS 7149, Université Paris Est Créteil, Université Paris Est, 94010 Créteil, France.
Rosana N ChehínInstituto de Medicina Molecular y Celular Aplicada (IMMCA) CONICET/UNT and SIPROSA, Tucumán T4000ILI, Argentina.
Patrick P MichelInstitut du Cerveau et de la Moelle épinière (ICM), Inserm U 1127, CNRS UMR 7225, Sorbonne Université, F-75013 Paris, France.
Rita Raisman-VozariInstitut du Cerveau et de la Moelle épinière (ICM), Inserm U 1127, CNRS UMR 7225, Sorbonne Université, F-75013 Paris, France. ritaraisman@gmail.com.
Centre National de la Recherche Scientifique · FRConsejo Nacional de Investigaciones Científicas y Técnicas · ARNational University of Salta · ARUniversidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

alpha-SynucleinCytokinesHumansInflammation MediatorsMicrogliaModels, BiologicalMolecular StructureNeurodegenerative DiseasesNeuronsPhosphatidylinositol 3-KinasesReceptors, Purinergic P2X7RifampinSignal TransductionToll-Like Receptor 2alpha-SynucleinCytokinesdehydrorifampicinInflammation MediatorsPhosphatidylinositol 3-KinasesReceptors, Purinergic P2X7RifampinTLR2 protein, humanToll-Like Receptor 2aggregationcytokinesmicroglianeuroinflammationneuronal survivalParkinson’s diseaseα-synuclein

Identifiers

PMID31349736
PMCPMC6721546
OpenAlexW2963298839

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.