Evidence map›Paper›PMID 31349708›Full record

ArticleBiomolecules2019

Antrodia cinnamomea Enhances Chemo-Sensitivity of 5-FU and Suppresses Colon Tumorigenesis and Cancer Stemness via Up-Regulation of Tumor Suppressor miR-142-3p.

Yan-Jiun Huang, Vijesh Kumar Yadav, Prateeti Srivastava, Alexander Th Wu, Thanh-Tuan Huynh, Po-Li Wei, Chi-Ying F Huang, Tse-Hung Huang

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Evidence-Based Nutraceuticals Derived fromFoods (Basel, Switzerland) · 2025
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  4. International journal of molecular sciences · 2025
    Article
  5. Review
  6. Review
  7. Review
  8. Natural Products Treat Colorectal Cancer by Regulating miRNA.Pharmaceuticals (Basel, Switzerland) · 2023
    Review
  9. The Advances in Epigenetics for Cancer Radiotherapy.International journal of molecular sciences · 2022
    Review
  10. Article
  11. Article
  12. Patient-Derived Tumor Chemosensitization of GKB202, anMolecules (Basel, Switzerland) · 2021
    Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Yan-Jiun HuangDepartment of Surgery, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Vijesh Kumar YadavThe Division of Translational Medicine, Graduate Institute of Biomedical Informatics, Taipei Medical University, Taipei 110, Taiwan.
Prateeti SrivastavaThe Division of Translational Medicine, Graduate Institute of Biomedical Informatics, Taipei Medical University, Taipei 110, Taiwan.
Alexander Th WuThe PhD Program for Translational Medicine, College of Science and Technology, Taipei Medical University and Academia Sinica, Taipei 110, Taiwan.
Thanh-Tuan HuynhCenter for Molecular Biomedicine, University of Medicine and Pharmacy, Ho Chi Minh City 217, Vietnam.
Po-Li WeiDepartment of Surgery, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Chi-Ying F HuangInstitute of Biopharmaceutical Sciences, National Yang Ming University, Taipei 112, Taiwan.
Tse-Hung HuangDepartment of Traditional Chinese Medicine, Chang Gung Memorial Hospital, Keelung 204, Taiwan. huangtsehung@gmail.com.
Taipei Medical University · TWTaipei Medical University Hospital · TWChang Gung University of Science and Technology · TWNational Yang Ming Chiao Tung University · TWUniversity of Medicine and Pharmacy at Ho Chi Minh City · VN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

5-Fluorouracil (5-FU) regimen remains the backbone of the first-line agent to treat colon cancer, but often these patients develop resistance. Cancer stem cells (CSC's) are considered as one of the key contributors in the development of drug resistance and tumor recurrence. We aimed to provide preclinical evidence for

Indexed as

AnimalsAntrodiaBiological ProductsCell Line, TumorCell ProliferationCell SurvivalColonic NeoplasmsDrug SynergismFemaleFluorouracilGene Expression Regulation, NeoplasticHCT116 CellsHumansMiceMicroRNAsNeoplastic Stem CellsBiological ProductsFluorouracilMicroRNAsMIRN142 microRNA, human5-FUACcolon cancerEMTmiR-142-3pstemness

Identifiers

PMID31349708
PMCPMC6723279
OpenAlexW2962906020

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.