Evidence map›Paper›PMID 31349625›Full record

ArticleMarine drugs2019

A Novel Polyhalogenated Monoterpene Induces Cell Cycle Arrest and Apoptosis in Breast Cancer Cells.

Menna El Gaafary, Susanne Hafner, Sophia J Lang, Lu Jin, Omar M Sabry, Carl V Vogel, Christopher D Vanderwal, Tatiana Syrovets, Thomas Simmet

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Frontiers in oncology · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Chrysosplenol d, a Flavonol fromInternational journal of molecular sciences · 2020
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Menna El GaafaryInstitute of Pharmacology of Natural Products and Clinical Pharmacology, Ulm University, D-89081 Ulm, Germany.
Susanne HafnerInstitute of Pharmacology of Natural Products and Clinical Pharmacology, Ulm University, D-89081 Ulm, Germany.
Sophia J LangInstitute of Pharmacology of Natural Products and Clinical Pharmacology, Ulm University, D-89081 Ulm, Germany.
Lu JinInstitute of Pharmacology of Natural Products and Clinical Pharmacology, Ulm University, D-89081 Ulm, Germany.
Omar M SabryDepartment of Pharmacognosy, College of Pharmacy, Cairo University, Cairo 11562, Egypt.ORCID 0000-0002-5796-2708
Carl V VogelDepartment of Chemistry, 1102 Natural Sciences II, University of California, Irvine, CA 92697-2025, USA.
Christopher D VanderwalDepartment of Chemistry, 1102 Natural Sciences II, University of California, Irvine, CA 92697-2025, USA.
Tatiana SyrovetsInstitute of Pharmacology of Natural Products and Clinical Pharmacology, Ulm University, D-89081 Ulm, Germany. tatiana.syrovets@uni-ulm.de.ORCID 0000-0002-6751-2233
Thomas SimmetInstitute of Pharmacology of Natural Products and Clinical Pharmacology, Ulm University, D-89081 Ulm, Germany. thomas.simmet@uni-ulm.de.
Universität Ulm · DECairo University · EGUniversity of California, Irvine · US

Funding

Stae Ministry of Baden-Württemberg for Sciences, Research and Arts AZKIM
6 · The paper itself

Abstract

Breast cancer is the most common cancer type and a primary cause of cancer mortality among females worldwide. Here, we analyzed the anticancer efficacy of a novel bromochlorinated monoterpene, PPM1, a synthetic analogue of polyhalogenated monoterpenes from

Indexed as

Antineoplastic AgentsApoptosisBreastBreast NeoplasmsCaspase InhibitorsCaspasesCell Cycle CheckpointsCell Line, TumorCell ProliferationCell SurvivalEpithelial CellsFemaleG2 PhaseHistonesHumansMCF-7 CellsAntineoplastic AgentsCaspase InhibitorsCaspasesHistonesMonoterpenesapoptosiscell cyclechick chorioallantoic membrane assayPlocamiumpolyhalogenated monoterpenesred algae

Identifiers

PMID31349625
PMCPMC6723102
OpenAlexW2962871523

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.