SynthesisPediatric research2020
Nutrition and the developing brain: the road to optimizing early neurodevelopment: a systematic review.
Synthesis in Pediatric research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 2 syntheses or guidelines pooled it, 86 citations in OpenAlex.
- Pooled it
- Human Milk Feeding in Inherited Metabolic Disorders: A Systematic Review of Growth, Metabolic Control, and Neurodevelopment Outcomes.Journal of inherited metabolic disease · 2025Pooled it
- Pregnancy diet based on ancestral patterns increases growth in subcortical fetal brain regions.Proceedings of the National Academy of Sciences of the United States of America · 2026Trial
- Trial
- Effects of kinesiology taping on swallowing functions in newborns with swallowing difficulties: a randomized controlled pilot study.Revista da Associacao Medica Brasileira (1992) · 2023Trial
- Percent Body Fat Content Measured by Plethysmography in Infants Randomized to High- or Usual-Volume Feeding after Very Preterm Birth.The Journal of pediatrics · 2021Trial
- Enhanced Energy Metabolism and Developmental Signaling in Neonatal Brains of Female Piglets Parenterally Fed with 18-Carbon n-3 Fatty Acid-Based Vegaven Compared with Fish Oil-Containing Lipid Emulsion.Current developments in nutrition · 2026Article
- Donor human milk and structural brain development in very preterm infants.Pediatric research · 2026Observational
- WHO exclusive breastfeeding recommendation and cognitive development in Germany.Scientific reports · 2026Article
- Effects of Early Infant Nutrition on Aperiodic Exponent From 2 to 12 Months Using EEG Analysis.Psychophysiology · 2026Article
- Harmonization of slice thickness through resampling improves comparability of MRI-derived neonatal brain volumes.Frontiers in radiology · 2026Article
- Translation, cross-cultural adaptation and preliminary application of the premature infant oral motor intervention in Chinese neonatal nursing practice: a pilot randomized controlled trial.Frontiers in pediatrics · 2026Article
- Awareness of neonatal heat illness: a fatal outcome in a late preterm infant.BMJ case reports · 2025Article
- Factors Influencing Exclusive Breastfeeding Amongst Arab Mothers in Israel: Social, Cultural, and Occupational Aspects.Healthcare (Basel, Switzerland) · 2025Article
- Medium-chain triglycerides tricaprin TC10 and tricaprylin TC8 attenuated HFD-induced cognitive decline in a manner dependent on or independent of GLP-1.Scientific reports · 2025Article
- Transforming the electronic health record from a documentation application to an automated diet program for personalizing neonatal nutrition and improving feeding administration safety through process improvement.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2025Article
- Maternal Omega-6/Omega-3 Concentration Ratio During Pregnancy and Infant Neurodevelopment: The ECLIPSES Study.Nutrients · 2025Article
- Article
- Infant and early childhood physical health assessments in the HEALthy Brain and Child Development (HBCD) Study.Developmental cognitive neuroscience · 2024Article
- Neurohabilitation of Cognitive Functions in Pediatric Epilepsy Patients through LEGOBrain sciences · 2024Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundNeonatal intensive care practices have resulted in marked improvements in the survival of premature infants; however, they remain at significant risk for adverse neurodevelopmental outcomes. The impact of current nutritional practices on brain development following early extra-uterine exposure in premature infants is not well known.
methodsWe performed a systematic review to investigate nutritional effects on postnatal brain development in healthy term and prematurely born infants utilizing advanced magnetic resonance imaging tools.
resultsSystematic screen yielded 595 studies for appraisal. Of these, 22 total studies were selected for inclusion in the review, with findings summarized in a qualitative, descriptive fashion.
conclusionFat and energy intake are associated with improved brain volume and development in premature infants. While breast milk intake and long-chain polyunsaturated fatty acid supplementation has been proven beneficial in term infants, the impact in preterm infants is less well understood.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.