ArticleiScience2019
Odorant Inhibition in Mosquito Olfaction.
Article in iScience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- Integrated strategies for mosquito-borne disease control: a comprehensive review with emphasis on repellents and China's practices.Parasites & vectors · 2026Review
- Evaluation of fruit combinations as potential liquid attractants for hydrogel bait applications targeting Aedes mosquitoes.Parasites & vectors · 2026Article
- The olfactory neurobiology and chemical ecology of mosquito attraction to plant nutrient sources.Proceedings. Biological sciences · 2025Review
- The chemosensory world of mosquitoes: olfactory receptors and their role in blocking mosquito-borne disease transmission.Parasites & vectors · 2025Review
- Differences in human skin volatiles between populations with high and low attraction to mosquitoes.Parasites & vectors · 2025Article
- The dual coding of a single sex pheromone receptor in Asian honeybee Apis cerana.Communications biology · 2024Article
- Single amino acid residue mediates reciprocal specificity in two mosquito odorant receptors.eLife · 2022Article
- The ovipositor cue indole inhibits animal host attraction in Aedes aegypti (Diptera: Culicidae) mosquitoes.Parasites & vectors · 2022Article
- Article
- Odorant inhibition in mosquito olfaction mediated by inverse agonists.Biochemical and biophysical research communications · 2022Article
- Mosquito odorant receptor sensitive to natural spatial repellents and inhibitory compounds.Insect biochemistry and molecular biology · 2022Article
- Non-synaptic interactions between olfactory receptor neurons, a possible key feature of odor processing in flies.PLoS computational biology · 2021Article
- Olfactory systems across mosquito species.Cell and tissue research · 2021Review
- COInsect biochemistry and molecular biology · 2020Article
- DEET and other repellents are inhibitors of mosquito odorant receptors for oviposition attractants.Insect biochemistry and molecular biology · 2019Article
- Odorant receptors from Culex quinquefasciatus and Aedes aegypti sensitive to floral compounds.Insect biochemistry and molecular biology · 2019Article
- Volatile allosteric antagonists of mosquito odorant receptors inhibit human-host attraction.The Journal of biological chemistryArticle
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
How chemical signals are integrated at the peripheral sensory system of insects is still an enigma. Here we show that when coexpressed with Orco in Xenopus oocytes, an odorant receptor from the southern house mosquito, CquiOR32, generated inward (regular) currents when challenged with cyclohexanone and methyl salicylate, whereas eucalyptol and fenchone elicited inhibitory (upward) currents. Responses of CquiOR32-CquiOrco-expressing oocytes to odorants were reduced in a dose-dependent fashion by coapplication of inhibitors. This intrareceptor inhibition was also manifested in vivo in fruit flies expressing the mosquito receptor CquiOR32, as well in neurons on the antennae of the southern house mosquito. Likewise, an orthologue from the yellow fever mosquito, AaegOR71, showed intrareceptor inhibition in the Xenopus oocyte recording system and corresponding inhibition in antennal neurons. Inhibition was also manifested in mosquito behavior. Blood-seeking females were repelled by methyl salicylate, but repellence was significantly reduced when methyl salicylate was coapplied with eucalyptol.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.