Evidence map›Paper›PMID 31349087›Full record

ArticleNanomedicine : nanotechnology, biology, and medicine2019

Towards a nanoparticle-based prophylactic for maternal autoantibody-related autism.

Amir Bolandparvaz, Rian Harriman, Kenneth Alvarez, Kristina Lilova, Zexi Zang, Andy Lam, Elizabeth Edmiston, Alexandra Navrotsky, Natalia Vapniarsky, Judy Van De Water and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanomedicine : nanotechnology, biology, and medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Amir BolandparvazUniversity of California, Davis, Department of Biomedical Engineering, Davis, CA, USA.
Rian HarrimanUniversity of California, Davis, Department of Biomedical Engineering, Davis, CA, USA.
Kenneth AlvarezUniversity of California, Davis, Department of Biomedical Engineering, Davis, CA, USA.
Kristina LilovaUniversity of California, Davis, Peter A. Rock Thermochemistry Laboratory and NEAT, Davis, CA, USA.
Zexi ZangUniversity of California, Davis, Department of Biomedical Engineering, Davis, CA, USA.
Andy LamUniversity of California, Davis, Peter A. Rock Thermochemistry Laboratory and NEAT, Davis, CA, USA.
Elizabeth EdmistonUniversity of California, Davis, Department of Internal Medicine, Division of Rheumatology, Allergy, and Clinical Immunology, Davis, CA, USA.
Alexandra NavrotskyUniversity of California, Davis, Peter A. Rock Thermochemistry Laboratory and NEAT, Davis, CA, USA.
Natalia VapniarskyUniversity of California, Davis, Department of Pathology Microbiology and Immunology, Davis, CA, USA.
Judy Van De WaterUniversity of California, Davis, Department of Internal Medicine, Division of Rheumatology, Allergy, and Clinical Immunology, Davis, CA, USA; University of California, Davis, M.I.N.D. (Medical Investigation of Neurodevelopmental Disorders), Davis, CA, USA.
Jamal S LewisUniversity of California, Davis, Department of Biomedical Engineering, Davis, CA, USA. Electronic address: jamlewis@ucdavis.edu.

Funding

UC Davis Center for Children's Environmental Health (CCEH)P01ES011269 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI VAN DE WATER, JUDY A. · 2001 to 2018
$12.5M
Research Project: Pathologic Significance of Maternal AutoantibodiesP50HD103526 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LEONARD J. ABBEDUTO, Melissa Dawn Bauman · 2020 to 2026
$9.7M
Rodent Behavior CoreU54HD079125 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HAGERMAN, RANDI J. · 2013 to 2019
$8.5M
Leveraging Engineering Approaches to understand Cryptococcal Vomocytosis from Immune CellsR35GM125012 · NIGMS · UNIVERSITY OF FLORIDA · PI Jamal S Lewis · 2017 to 2026
$3.2M
Particulate-based in vivo modulation for immunotherapy of Rheumatoid ArthritisR01AI139399 · NIAID · UNIVERSITY OF FLORIDA · PI LEWIS, JAMAL S · 2019 to 2023
$1.9M
NIAID NIH HHS R01 AI139399NICHD NIH HHS P50 HD103526NICHD NIH HHS U54 HD079125NIEHS NIH HHS P01 ES011269NIGMS NIH HHS R35 GM125012
6 · The paper itself

Abstract

Recently, the causative agents of Maternal Autoantibody-Related (MAR) autism, pathological autoantibodies and their epitopic targets (e.g. lactate dehydrogenase B [LDH B] peptide), have been identified. Herein, we report on the development of Systems for Nanoparticle-based Autoantibody Reception and Entrapment (SNAREs), which we hypothesized could scavenge disease-propagating MAR autoantibodies from the maternal blood. To demonstrate this functionality, we synthesized 15 nm dextran iron oxide nanoparticles surface-modified with citric acid, methoxy PEG(10 kDa) amine, and LDH B peptide (33.8 μg peptide/cm

Indexed as

AutoantibodiesNanoparticlesPeptidesAnimalsAutistic DisorderDisease Models, AnimalFemaleHumansMacrophagesMaleMiceRAW 264.7 CellsAutoantibodiesPeptidesIron oxide(2)Maternal autoantibody-related autism(1)nanoparticles(3)Peptide-functionalized(4)

Identifiers

PMID31349087
PMCPMC7197945

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.