ArticleNeuroImage2019
Identifying inter-individual differences in pain threshold using brain connectome: a test-retest reproducible study.
Article in NeuroImage, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 45 citations in OpenAlex.
- Predicting Pain: Electroencephalography Signatures of Neural Integration During Experimental Tonic Thermal Pain.European journal of pain (London, England) · 2026Article
- A Replicable and Generalizable Neuroimaging-Based Indicator of Pain Sensitivity Across Individuals.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- EEG oscillations reveal neuroplastic changes in pain processing associated with long-term meditation.Scientific reports · 2025Article
- Advances and challenges in neuroimaging-based pain biomarkers.Cell reports. Medicine · 2024Review
- Midbrain glutamatergic circuit mechanism of resilience to socially transferred allodynia in male mice.Nature communications · 2024Article
- Targeting Prefrontal Cortex Dysfunction in Pain.The Journal of pharmacology and experimental therapeutics · 2024Review
- Intact painful sensation but enhanced non-painful sensation in individuals with autistic traits.Frontiers in psychiatry · 2024Article
- The psychophysiology of music-based interventions and the experience of pain.Frontiers in psychology · 2024Review
- Thalamocortical Mechanisms Underlying Real and Imagined Acupuncture.Biomedicines · 2023Article
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- Article
- Combining Regional and Connectivity Metrics of Functional Magnetic Resonance Imaging and Diffusion Tensor Imaging for Individualized Prediction of Pain Sensitivity.Frontiers in molecular neuroscience · 2022Article
- The brain's structural differences between postherpetic neuralgia and lower back pain.Scientific reports · 2021Article
- Thermal Pain Thresholds Are Significantly Associated with Plasma Proteins of the Immune System in Chronic Widespread Pain-An Exploratory Pilot Study Using Multivariate and Network Analyses.Journal of clinical medicine · 2021Article
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- How expectations of pain elicited by consciously and unconsciously perceived cues unfold over time.NeuroImage · 2021Article
- From receptors to the brain: Psychophysical clues to taste physiology.Current opinion in physiology · 2021Article
- Predicting Individual Pain Thresholds From Morphological Connectivity Using Structural MRI: A Multivariate Analysis Study.Frontiers in neuroscience · 2021Article
- Individual pain sensitivity is associated with resting-state cortical activities in healthy individuals but not in patients with migraine: a magnetoencephalography study.The journal of headache and pain · 2020Article
- Sensorimotor Peak Alpha Frequency Is a Reliable Biomarker of Prolonged Pain Sensitivity.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Individuals are unique in terms of brain and behavior. Some are very sensitive to pain, while others have a high tolerance. However, how inter-individual intrinsic differences in the brain are related to pain is unknown. Here, we performed longitudinal test-retest analyses to investigate pain threshold variability among individuals using a resting-state fMRI brain connectome. Twenty-four healthy subjects who received four MRI sessions separated by at least 7 days were included in the data analysis. Subjects' pain thresholds were measured using two modalities of experimental pain (heat and pressure) on two different locations (heat pain: leg and arm; pressure pain: leg and thumbnail). Behavioral results showed strong inter-individual variability and strong within-individual stability in pain threshold. Resting state fMRI data analyses showed that functional connectivity profiles can accurately identify subjects across four sessions, indicating that an individual's connectivity profile may be intrinsic and unique. By using multivariate pattern analyses, we found that connectivity profiles could be used to predict an individual's pain threshold at both within-session and between-session levels, with the most predictive contribution from medial-frontal and frontal-parietal networks. These results demonstrate the potential of using a resting-state fMRI brain connectome to build a 'neural trait' for characterizing an individual's pain-related behavior, and such a 'neural trait' may eventually be used to personalize clinical assessments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.