Evidence map›Paper›PMID 31349005›Full record

ArticleNeuroscience2020

Tonic Calcium-Activated Chloride Current Sustained by ATP Release and Highly Desensitizing Human P2X1 Receptors.

Agenor Limon, Garo Hagopian, Jorge M Reyes-Ruiz, Ricardo Miledi

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Agenor LimonDepartment of Neurology, Mitchel Center for Neurodegenerative Diseases, School of Medicine, University of Texas Medical Branch at Galveston, USA; Department of Neurobiology and Behavior, School of Medicine, University of California Irvine, USA. Electronic address: aglimonr@utmb.edu.
Garo HagopianDepartment of Neurobiology and Behavior, School of Medicine, University of California Irvine, USA.
Jorge M Reyes-RuizDepartment of Neurobiology and Behavior, School of Medicine, University of California Irvine, USA.
Ricardo MilediDepartment of Neurobiology and Behavior, School of Medicine, University of California Irvine, USA.
University of California, Irvine · USThe University of Texas Medical Branch at Galveston · US

Funding

Multidimensional Analysis of Synaptic Dysfunction in SchizophreniaR21MH113177 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI LIMON, AGENOR, VAWTER, MARQUIS PHILIP · 2017 to 2018
$425k
NIMH NIH HHS R21 MH113177
6 · The paper itself

Abstract

Extracellular adenosine triphosphate (ATP) participates in maintaining the vascular tone in the CNS, particularly in the retina, via the tonic activity of ligand gated activated P2X1 receptors. P2X1 receptors are characterized by their high affinity for ATP and their strong desensitization to concentrations of ATP that are 200-fold lower than their EC

Indexed as

Adenosine TriphosphateCalciumChloridesReceptors, Purinergic P2X1AnimalsCalcium ChlorideHumansOocytesXenopusAdenosine TriphosphateCalciumCalcium ChlorideChloridesReceptors, Purinergic P2X1ATP releasepurinergic signalingtonic activityvascular tone

Identifiers

PMID31349005
PMCPMC6980929
OpenAlexW2964158390

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.