ArticleMolecular and cellular endocrinology2019
A chromosomal inversion predicts the expression of sex steroid-related genes in a species with alternative behavioral phenotypes.
Article in Molecular and cellular endocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Opposing behavioral roles for a single gene in a species with a supergene polymorphism.bioRxiv : the preprint server for biology · 2026Article
- Allele-specific cis-regulatory methylation of the gene for vasoactive intestinal peptide in white-throated sparrows.Genes, brain, and behavior · 2022Article
- Supergenes on steroids.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Genome-wide variation in DNA methylation linked to developmental stage and chromosomal suppression of recombination in white-throated sparrows.Molecular ecology · 2021Article
- Inside the supergene of the bird with four sexes.Hormones and behavior · 2020Review
- A supergene-linked estrogen receptor drives alternative phenotypes in a polymorphic songbird.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Vasoactive intestinal peptide as a mediator of the effects of a supergene on social behaviour.Proceedings. Biological sciences · 2020Article
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Abstract
In white-throated sparrows, a chromosomal rearrangement has led to alternative phenotypes that differ in sex steroid-dependent behaviors. The rearrangement has captured the genes estrogen receptor alpha and 5-alpha reductase, making these genes strong candidates for mediating the behavioral phenotypes. We report here that of the two genes, expression of estrogen receptor alpha mRNA differs between the morphs and predicts behavior to a much greater extent than does expression of 5-alpha reductase mRNA. Differentiation of estrogen receptor alpha, therefore, is likely more important for the behavioral phenotypes. We also found that in some brain regions, the degree to which testosterone treatment affects the expression of steroid-related genes depends strongly on morph. A large morph difference in estrogen receptor alpha mRNA expression in the amygdala appears to be independent of plasma testosterone; this difference persists during the non-breeding season and is detectable in nestlings at post-hatch day seven. The latter result suggests a substrate for organizational effects of hormones during development.
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