Evidence map›Paper›PMID 31348892›Full record

ReviewTranslational research : the journal of laboratory and clinical medicine2019

CTC analysis: an update on technological progress.

Izhar S Batth, Abhisek Mitra, Sierra Rood, Scott Kopetz, David Menter, Shulin Li

Open access · greenAbstract readReview
In one paragraph

Review in Translational research : the journal of laboratory and clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Circulating tumor cellsTranslational breast cancer research : a journal focusing on translational research in breast cancer · 2024
    Review
  11. Review
  12. Detection of Circulating Tumor Cells Using the Attune NxT.International journal of molecular sciences · 2022
    Article
  13. Article
  14. Review
  15. Tissue factor: a neglected role in cancer biology.Journal of thrombosis and thrombolysis · 2022
    Review
  16. Article
  17. SimultaneousAnnals of translational medicine · 2021
    Article
  18. Article
  19. Review
  20. [Advances in Clinical Application of Liquid Biopsy in Non-small Cell Lung Cancer].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Izhar S BatthDepartment of Pediatrics - Research, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Abhisek MitraDepartment of Pediatrics - Research, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Sierra RoodAugustana College, Rock Island, Illinois.
Scott KopetzDepartment of Gastrointestinal (GI) Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address: SKopetz@mdanderson.org.
David MenterDepartment of Gastrointestinal (GI) Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address: dmenter@mdanderson.org.
Shulin LiDepartment of Pediatrics - Research, The University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address: SLi4@mdanderson.org.
The University of Texas MD Anderson Cancer Center · USAugustana College · US

Funding

Center for Clinical and Translational Sciences (CCTS)KL2TR000370 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MCPHERSON, DAVID D · 2012 to 2016
$4.3M
Pathway Specific Functional Biomarkers for the Early Detection of Liver CancerU01CA230690 · NCI · GEORGE WASHINGTON UNIVERSITY · PI MISHRA, LOPA, SHETTY, KIRTI · 2018 to 2022
$3.4M
Develop CTC capture technology for both mesenchymal and non-mesenchymal tumorsR01EB026291 · NIBIB · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LI, SHULIN · 2018 to 2021
$1.4M
NCATS NIH HHS KL2 TR000370NCI NIH HHS U01 CA230690NIBIB NIH HHS R01 EB026291
6 · The paper itself

Abstract

There is a growing need for a more accurate, real-time assessment of tumor status and the probability of metastasis, relapse, or response to treatment. Conventional means of assessment include imaging and tissue biopsies that can be highly invasive, may not provide complete information of the disease's heterogeneity, and not ideal for repeat analysis. Therefore, a less-invasive means of acquiring similar information at greater time points is necessary. Liquid biopsies are samples of a patients' peripheral blood and hold potential of addressing these criteria. Ongoing research has revealed that a tumor can release circulating cells, genetic materials (DNA or RNA), and exosomes into circulation. These potential biomarkers can be captured in a liquid biopsy and analyzed to determine disease status. To achieve these goals, numerous technologies have been developed. In this review, we discuss both prominent and newly developed technologies for circulating tumor cell capture and analysis and their clinical impact.

Indexed as

Neoplastic Cells, CirculatingBiomarkers, TumorHumansMicrofluidicsNeoplasmsBiomarkers, Tumor

Identifiers

PMID31348892
PMCPMC6755047
OpenAlexW2960451366

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.