ArticleCell2019
A Paranigral VTA Nociceptin Circuit that Constrains Motivation for Reward.
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Article in Cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 1 of them a synthesis that pooled it.
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82citing papers in PubMed, 1 pooled it
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82 citing papers in PubMed, 1 synthesis or guideline pooled it, 128 citations in OpenAlex.
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- B cell-derived nociceptin/orphanin FQ contributes to impaired glucose tolerance and insulin resistance in obesity.iScience · 2025Article
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- Altered Neural Activity in the Mesoaccumbens Pathway Underlies Impaired Social Reward Processing in Shank3-Deficient Rats.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Septo-hypothalamic regulation of binge-like alcohol consumption by the nociceptin system.Cell reports · 2025Article
22 more citing papers are in PubMed but not listed here.
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Authors and funding
19 authors at 4 institutions in 1 country.
Kyle E ParkerDepartments of Anesthesiology, Division of Basic Research, Anatomy and Neurobiology, and Washington University Pain Center, Washington University School of Medicine, St. Louis, MO, USA.
Christian E PedersenDepartments of Anesthesiology, Division of Basic Research, Anatomy and Neurobiology, and Washington University Pain Center, Washington University School of Medicine, St. Louis, MO, USA; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO 63130, USA.
Adrian M GomezDepartments of Anesthesiology, Division of Basic Research, Anatomy and Neurobiology, and Washington University Pain Center, Washington University School of Medicine, St. Louis, MO, USA.
Skylar M SpanglerDepartments of Anesthesiology, Division of Basic Research, Anatomy and Neurobiology, and Washington University Pain Center, Washington University School of Medicine, St. Louis, MO, USA; Neuroscience Program (DBBS), Washington University School of Medicine, St. Louis, MO, USA.
Marie C WalickiDepartments of Anesthesiology, Division of Basic Research, Anatomy and Neurobiology, and Washington University Pain Center, Washington University School of Medicine, St. Louis, MO, USA.
Shelley Y FengDepartments of Anesthesiology, Division of Basic Research, Anatomy and Neurobiology, and Washington University Pain Center, Washington University School of Medicine, St. Louis, MO, USA.
Sarah L StewartDepartments of Anesthesiology, Division of Basic Research, Anatomy and Neurobiology, and Washington University Pain Center, Washington University School of Medicine, St. Louis, MO, USA.
James M OtisDepartment of Psychiatry, University of North Carolina, Chapel Hill, NC, USA.
Ream Al-HasaniDepartments of Anesthesiology, Division of Basic Research, Anatomy and Neurobiology, and Washington University Pain Center, Washington University School of Medicine, St. Louis, MO, USA; Department of Pharmaceutical and Administrative Sciences, St. Louis College of Pharmacy, St. Louis, MO, USA; Center for Clinical Pharmacology, St. Louis College of Pharmacy and Washington University School of Medicine, St. Louis, MO, USA; Division of Biology and Biomedical Sciences, Washington University School of Medicine, St. Louis, MO, USA.
Jordan G McCallDepartments of Anesthesiology, Division of Basic Research, Anatomy and Neurobiology, and Washington University Pain Center, Washington University School of Medicine, St. Louis, MO, USA; Department of Pharmaceutical and Administrative Sciences, St. Louis College of Pharmacy, St. Louis, MO, USA; Center for Clinical Pharmacology, St. Louis College of Pharmacy and Washington University School of Medicine, St. Louis, MO, USA; Division of Biology and Biomedical Sciences, Washington University School of Medicine, St. Louis, MO, USA.
Kristina SakersDepartment of Genetics, Washington University School of Medicine, St. Louis, MO, USA; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Dionnet L BhattiDepartments of Anesthesiology, Division of Basic Research, Anatomy and Neurobiology, and Washington University Pain Center, Washington University School of Medicine, St. Louis, MO, USA.
Bryan A CopitsDepartments of Anesthesiology, Division of Basic Research, Anatomy and Neurobiology, and Washington University Pain Center, Washington University School of Medicine, St. Louis, MO, USA.
Robert W GereauDepartments of Anesthesiology, Division of Basic Research, Anatomy and Neurobiology, and Washington University Pain Center, Washington University School of Medicine, St. Louis, MO, USA.
Thomas JhouDepartment of Neuroscience, Medical University of South Carolina, Charleston, SC, USA.
Thomas J KashDepartment of Pharmacology and Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina, Chapel Hill, NC, USA.
Joseph D DoughertyDepartment of Genetics, Washington University School of Medicine, St. Louis, MO, USA; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Garret D StuberDepartment of Psychiatry, University of North Carolina, Chapel Hill, NC, USA; Neuroscience Center, University of North Carolina, Chapel Hill, NC, USA; Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC, USA.
Michael R BruchasDepartments of Anesthesiology, Division of Basic Research, Anatomy and Neurobiology, and Washington University Pain Center, Washington University School of Medicine, St. Louis, MO, USA; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO 63130, USA; Division of Biology and Biomedical Sciences, Washington University School of Medicine, St. Louis, MO, USA; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA. Electronic address: mbruchas@uw.edu.
Washington University in St. Louis · USUniversity of North Carolina at Chapel Hill · USMedical University of South Carolina · USUniversity of Health Sciences and Pharmacy · US
Funding
Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0MWU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8MWashington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4MUniversity of Washington Center of Excellence in Opioid Addiction ResearchP30DA048736 · NIDA · UNIVERSITY OF WASHINGTON · PI Charles Chavkin · 2019 to 2026
$13.0MBIOMEDICAL RESEARCH TRAINING IN DRUG ABUSET32DA007261 · NIDA · WASHINGTON UNIVERSITY · PI ARPANA AGRAWAL, Jose A Moron-Concepcion · 1991 to 2026
$8.8MSystems and Molecular Neurobiology Training ProgramT32GM008151 · NIGMS · WASHINGTON UNIVERSITY · PI SNYDER, LAWRENCE H · 1985 to 2019
$6.5MNeural circuit elements that orchestrate cue-reward associationsR37DA032750 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Garret D Stuber · 2017 to 2026
$4.5MLateral Hypothalamic Circuits for Feeding and ReinforcementR01DA038168 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI STUBER, GARRET D · 2014 to 2025
$4.0MDISSECTING DYNORPHIN-KAPPA OPIOID MEDIATED REINSTATEMENT OF NICOTINE PREFERENCER37DA033396 · NIDA · WASHINGTON UNIVERSITY · PI Michael R. Bruchas · 2018 to 2026
$3.8MAN INDUCIBLE MOLECULAR MEMORY SYSTEM TO RECORD TRANSIENT STATES OF CNS CELLSU01MH109133 · NIMH · WASHINGTON UNIVERSITY · PI MITRA, ROBI D · 2015 to 2017
$3.6M21ST CENTURY IMAGING SCIENCES: GRADUATE STUDENT TRAININGT32EB014855 · NIBIB · WASHINGTON UNIVERSITY · PI JOSEPH P CULVER, JOSEPH A O'SULLIVAN · 2012 to 2026
$3.1MDEFINING DYNORPHIN-CRF CIRCUITS IN STRESS AND NICOTINE BEHAVIORSR00DA038725 · NIDA · ST. LOUIS COLLEGE OF PHARMACY · PI AL-HASANI, REAM · 2017 to 2019
$747kNCATS NIH HHS UL1 TR000448NCATS NIH HHS UL1 TR002345NCI NIH HHS P30 CA091842NIBIB NIH HHS T32 EB014855NIDA NIH HHS F32 DA041184NIDA NIH HHS P30 DA048736NIDA NIH HHS R00 DA038725NIDA NIH HHS R01 DA038168NIDA NIH HHS R21 DA034929NIDA NIH HHS R37 DA032750NIDA NIH HHS R37 DA033396NIDA NIH HHS T32 DA007261NIGMS NIH HHS T32 GM008151NIMH NIH HHS U01 MH109133
Abstract
Nociceptin and its receptor are widely distributed throughout the brain in regions associated with reward behavior, yet how and when they act is unknown. Here, we dissected the role of a nociceptin peptide circuit in reward seeking. We generated a prepronociceptin (Pnoc)-Cre mouse line that revealed a unique subpopulation of paranigral ventral tegmental area (pnVTA) neurons enriched in prepronociceptin. Fiber photometry recordings during progressive ratio operant behavior revealed pnVTA
Indexed as
RewardAction PotentialsAnimalsBehavior, AnimalFemaleMaleMiceMice, Inbred C57BLMice, TransgenicMotivationNeuronsNociceptinNociceptin ReceptorOpioid PeptidesPatch-Clamp TechniquesProtein PrecursorsNociceptinNociceptin ReceptorOpioid PeptidesOprl1 protein, mouseprepronociceptinProtein PrecursorsReceptors, OpioidmotivationneuropeptidenociceptinNOPRopioidoptogeneticsorphanin FQphotometryrewardventral tegmental area
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