SynthesisMedicine2019
Risk factors for drug-resistant epilepsy: A systematic review and meta-analysis.
Synthesis in Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
67 citing papers in PubMed, 4 syntheses or guidelines pooled it, 136 citations in OpenAlex.
- Treatment outcome and its predictors among children with epilepsy on chronic follow-up in Ethiopia: a systematic review and meta-analysis.BMC public health · 2024Pooled it
- Epilepsy surgery for children with epileptic spasms: A systematic review and meta-analysis with focus on predictors and outcomes.Epilepsia open · 2024Pooled it
- Fruits for Seizures? A Systematic Review on the Potential Anti-Convulsant Effects of Fruits and their Phytochemicals.Current neuropharmacology · 2022Pooled it
- Treatment Outcome of Epileptic Patients Receiving Antiepileptic Drugs in Ethiopia: A Systematic Review and Meta-Analysis.Behavioural neurology · 2021Pooled it
- Safety and Efficacy of Natalizumab as Adjunctive Therapy for People With Drug-Resistant Epilepsy: A Phase 2 Study.Neurology · 2021Trial
- Factors associated with drug-resistant epilepsy in adults from Southern Kazakhstan.Future science OA · 2026Article
- Comparative multicenter evaluation of thalamic neuromodulation for treatment-resistant epilepsy in children.Epilepsia · 2026Observational
- Factors associated with drug-resistant epilepsy in children with epilepsy: a retrospective cohort study.Translational pediatrics · 2026Article
- Epilepsy and disability in adults with tuberous sclerosis complex: a 16-year retrospective analysis.Journal of neurology · 2026Article
- Risk factors for drug-resistant epilepsy according to sex: a cohort study conducted in a middle-income country.Arquivos de neuro-psiquiatria · 2026Article
- A Study on Protocol-based Treatment Change in Drug-resistant Epilepsy Patients in a Tertiary Care Center in Eastern India.Annals of Indian Academy of Neurology · 2026Article
- Data-Driven Clinical Phenotyping of Adult Epilepsy Using Latent Class Analysis: A Regional Cohort Study from Southern Kazakhstan.Journal of personalized medicine · 2026Article
- ESM-AnatTractNet: Advanced deep learning model of true positive eloquent white matter tractography to improve preoperative evaluation of pediatric epilepsy surgery.Medical image analysis · 2026Article
- Genetic spectrum and risk factor analysis for drug-resistant of early-onset epilepsy.Translational pediatrics · 2026Article
- The scale for estimating prognosis of epilepsy to predict in patients with epilepsy: a 506-patient cohort study.BMC neurology · 2026Article
- Nationwide Study of Pediatric Drug-Resistant Epilepsy in Estonia: Lower Incidence and Insights into Etiology.Pediatric reports · 2026Article
- Prescription Patterns of Antiseizure Medication in Adult Patients with Epilepsy in Kazakhstan (2021-2023).Medical sciences (Basel, Switzerland) · 2025Observational
- Ido1 or Ido2 deficiency in myeloid-derived cells attenuates TMEV-induced ictogenesis.Journal of neuroimmunology · 2025Article
- Microglia-specific Ido2 deficiency attenuates ictogenesis in the TMEV model of viral encephalitis.Brain, behavior, and immunity · 2025Article
- Morphometrics of the preserved post-surgical hemisphere in pediatric drug-resistant epilepsy and implications for post-operative cognition.bioRxiv : the preprint server for biology · 2025Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDrug resistant epilepsy (DRE) is very common among children and adults and studies had found some related risk factors for DRE, while the results were not consistent. The aim of this study was to identify risk factors for drug-resistant epilepsy.
methodsThree electronic databases (Medline, Embase and Cochrane library) were searched to identify studies with a cohort design reporting on epidemiologic evidence regarding risk factors for DRE.
resultsThe pooled prevalence of DRE in newly diagnosed epilepsy patients was 25% (95% CI 17-32%). Abnormal electroencephalography (EEG) (both slow wave and epileptiform discharges) (RR 2.80; 95% CI 1.95-4.0), status epilepticus (SE) (RR 11.60; 95% CI 7.39-18.22), symptomatic etiology (RR 3.36; 95% CI 2.53-4.46), multiple seizure types (RR 3.66; 95% CI 2.37-5.64) and febrile seizures (RR 3.43; 95% CI 1.95-6.02) were identified as strong risk factors for DRE. In addition, firm conclusions cannot be drawn for poor short-term outcomes of therapy, neurodevelopment delay and high initial seizure frequency for the heterogeneity of study results. The predictive effect of focus onset seizure was not stable after removing one study and switching the effect model. Age of onset was not risk factors for DRE.
conclusionsThe current meta-analysis identified potential risk factors for DRE. The results may contribute to better prevention strategies and treatments for DRE.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.