Evidence map›Paper›PMID 31348053›Full record

Trial reportAnesthesia and analgesia2020

Two-Week Multimodal Prehabilitation Program Improves Perioperative Functional Capability in Patients Undergoing Thoracoscopic Lobectomy for Lung Cancer: A Randomized Controlled Trial.

Zijia Liu, Tian Qiu, Lijian Pei, Yuelun Zhang, Li Xu, Yushang Cui, Naixin Liang, Shanqing Li, Wei Chen, Yuguang Huang

2 registry-linked trialsOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Anesthesia and analgesia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 122 papers, 32 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
122citing papers in PubMed, 32 pooled it
12.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05576766 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Impact of Enhanced Recovery After Surgery (ERAS) Pathway on Outcomes in Patients Undergoing Robot-Assisted Laparoscopic Radical Prostatectomy: A Randomized Controlled Trial

TypeinterventionalSponsorPeking University First HospitalRan2025 to 2026Enrolled54ConditionsProstate Cancer, Robot-Assisted Laparoscopic Radical Prostatectomy, Enhanced Recovery After Surgery (ERAS) Protocol, PrehabilitationArmsRoutine care, ERAS management pathway
NCT06215326 narecruitingnot on this mapstarted 2024, after this paper: background citation

Short-term Effects of Preoperative Exercise in Moderate-to-high Perioperative Risk Lung Cancer Patients(PRE-EXELUCA): a Prospective Randomized Controlled Clinical Trial

TypeinterventionalSponsorGuangdong Provincial People's HospitalRan2024 to 2027Enrolled100ConditionsLung CancerArmsmoderate-intensity continuous training, high-intensity interval training
3 · Its place in the literature

Who cites it

122 citing papers in PubMed, 32 syntheses or guidelines pooled it, 204 citations in OpenAlex.

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  2. Nonpharmacological dyspnoea-relief strategies in lung cancer: a systematic review and network meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2026
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62 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Zijia LiuFrom the Department of Anesthesiology, Peking Union Medical College Hospital, Beijing, China.
Tian QiuFrom the Department of Anesthesiology, Peking Union Medical College Hospital, Beijing, China.
Lijian PeiFrom the Department of Anesthesiology, Peking Union Medical College Hospital, Beijing, China.
Yuelun ZhangCentral Research Laboratory, Peking Union Medical College Hospital, Beijing, China.
Li XuFrom the Department of Anesthesiology, Peking Union Medical College Hospital, Beijing, China.
Yushang CuiDepartments of Thoracic Surgery.
Naixin LiangDepartments of Thoracic Surgery.
Shanqing LiDepartments of Thoracic Surgery.
Wei ChenEnteral and Parenteral Nutrition, Peking Union Medical College Hospital, Beijing, China.
Yuguang HuangFrom the Department of Anesthesiology, Peking Union Medical College Hospital, Beijing, China.
Chinese Academy of Medical Sciences & Peking Union Medical College · CNThoracic Surgery Foundation · USPeking Union Medical College Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with lung cancer often experience reduced functional capacity and quality of life after surgery. The current study investigated the impact of a short-term, home-based, multimodal prehabilitation program on perioperative functional capacity in patients undergoing video-assisted thoracoscopic surgery (VATS) lobectomy for nonsmall cell lung cancer (NSCLC).

methodsA randomized controlled trial was conducted with 73 patients. Patients in the prehabilitation group (n = 37) received a 2-week multimodal intervention program before surgery, including aerobic and resistance exercises, respiratory training, nutrition counseling with whey protein supplementation, and psychological guidance. Patients in the control group (n = 36) received the usual clinical care. The assessors were blinded to the patient allocation. The primary outcome was perioperative functional capacity measured as the 6-minute walk distance (6MWD), which was assessed at 1 day before and 30 days after surgery. A linear mixed-effects model was built to analyze the perioperative 6MWD. Other outcomes included lung function, disability and psychometric evaluations, length of stay (LOS), short-term recovery quality, postoperative complications, and mortality.

resultsThe median duration of prehabilitation was 15 days. The average 6MWD was 60.9 m higher perioperatively in the prehabilitation group compared to the control group (95% confidence interval [CI], 32.4-89.5; P < .001). There were no differences in lung function, disability and psychological assessment, LOS, short-term recovery quality, postoperative complications, and mortality, except for forced vital capacity (FVC; 0.35 L higher in the prehabilitation group, 95% CI, 0.05-0.66; P = .021).

conclusionsA 2-week, home-based, multimodal prehabilitation program could produce clinically relevant improvements in perioperative functional capacity in patients undergoing VATS lobectomy for lung cancer.

Indexed as

Cardiorespiratory FitnessHome Care Services, Hospital-BasedNutritional StatusPreoperative CareAgedBeijingBreathing ExercisesCarcinoma, Non-Small-Cell LungCounselingDietary SupplementsExercise ToleranceFemaleHealth StatusHumansLung NeoplasmsMaleWhey Proteins

Identifiers

PMID31348053
OpenAlexW2966813057

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.