ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2019
Effect of knockout of the ASIC3 on cardiovascular reflexes arising from hindlimb muscle in decerebrated rats.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 11 citations in OpenAlex.
- Pathological Mechanisms of Tendinopathy Pain: From Mechanical Overload to Neuroimmune-Vascular Crosstalk.Pain research & management · 2026Review
- Muscle afferent ASIC3 upregulation mediates the exacerbated exercise pressor reflex in male rats following hindlimb ischemia-reperfusion.Physiological reports · 2025Article
- Functional knock out of Acid Sensing Ion Channel 3 prevents the exaggerated exercise pressor reflex in rats exercising on a treadmill.Autonomic neuroscience : basic & clinical · 2025Article
- Novel mechanosensory role for acid sensing ion channel subtype 1a in evoking the exercise pressor reflex in rats with heart failure.The Journal of physiology · 2022Article
- ASIC3 knockout alters expression and activity of P2X3 in muscle afferent nerves of rat model of peripheral artery disease.FASEB bioAdvances · 2022Article
- Nerve growth factor in muscle afferent neurons of peripheral artery disease and autonomic function.Neural regeneration research · 2021Article
- Functional knockout of ASIC3 attenuates the exercise pressor reflex in decerebrated rats with ligated femoral arteries.American journal of physiology. Heart and circulatory physiology · 2020Article
- Effects of Lactate on One Class of Group III (CT3) Muscle Afferents.Frontiers in cellular neuroscience · 2020Article
- ASIC1a plays a key role in evoking the metabolic component of the exercise pressor reflex in rats.American journal of physiology. Heart and circulatory physiology · 2020Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The exercise pressor reflex is initiated by the contraction-induced activation of group III and IV muscle afferents. The reflex is manifested by increases in arterial blood pressure and cardiac output, which, in turn, are generated by increases in the sympathetic outflow to the heart and vasculature and decreases in the vagal outflow to the heart. In previous experiments, we used a pharmacological approach to assess the role played by the acid-sensing ion channel 3 (ASIC3) on group III and IV afferents in evoking the exercise pressor reflex. In the present experiments, we used an alternative approach, namely functional knockout (KO) of the ASIC3 gene, to confirm and extend our previous finding that pharmacological blockade of the ASIC3 had only a small impact on the expression of the exercise pressor reflex when the arterial supply to the contracting hindlimb muscles of rats was patent. Using this alternative approach, we compared the magnitude of the exercise pressor reflex evoked in ASIC3 KO rats with that evoked in their wild-type (WT) counterparts. We found both WT and ASIC3 KO rats displayed similar pressor responses to static contraction (WT,
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