Evidence map›Paper›PMID 31347379›Full record

ArticleAIDS research and human retroviruses2019

Treatment and Outcomes of Oropharyngeal Cancer in People with Human Immunodeficiency Virus.

Cristina E Brickman, Kathleen J Propert, Jessica S Merlin, Jeffrey C Liu, Sequoya Eady, Amy Mcghee-Jez, Camille Ragin, Surbhi Grover, Roger B Cohen, Robert Gross

Open access · greenAbstract readComparative StudyMulticenter Study
In one paragraph

Article in AIDS research and human retroviruses, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Cancer Treatment Disparities in People With HIV in the United States, 2001-2019.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024
    Article
  4. Impact of HIV on HPV-related cancers in men who have sex with men: a review.Frontiers in cellular and infection microbiology · 2024
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Cristina E BrickmanDivision of Infectious Diseases, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Kathleen J PropertDepartment of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania.
Jessica S MerlinDivision of Infectious Diseases, Department of Medicine, the University of Alabama at Birmingham, Birmingham, Alabama.
Jeffrey C LiuDepartment of Otolaryngology, Temple University, Philadelphia, Pennsylvania.
Sequoya EadyDivision of Infectious Diseases, Department of Medicine, the University of Alabama at Birmingham, Birmingham, Alabama.
Amy Mcghee-JezDivision of Hematology and Oncology, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania.
Camille RaginFox Chase Cancer Center at Temple University, Philadelphia, Pennsylvania.
Surbhi GroverDepartment of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania.
Roger B CohenDivision of Hematology and Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Robert GrossDivision of Infectious Diseases, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
University of Pennsylvania · USTemple University · US

Funding

Virus & Reservoirs CoreP30AI045008 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ROBERT GROSS · 1999 to 2026
$78.6M
CANCER CLINICAL EPIDEMIOLOGY TRAINING GRANTT32CA009679 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Richard Aplenc, Karen Glanz · 1992 to 2026
$11.1M
Prognostic value of quantitative HPV viral load in determining cervical cancer treatment response and recurrenceK08CA230170 · NCI · UNIVERSITY OF PENNSYLVANIA · PI GROVER, SURBHI · 2019 to 2023
$1.4M
NCI NIH HHS K08 CA230170NCI NIH HHS T32 CA009679NIAID NIH HHS P30 AI045008
6 · The paper itself

Abstract

HIV-positive people are at increased risk for malignancies associated with human papillomavirus (HPV) infection, including oropharyngeal squamous cell carcinoma (OPSCC). The purpose of this study was to determine whether cancer treatment disparities exist between HIV-positive and HIV-negative people with OPSCC. We conducted a retrospective cohort study comparing OPSCC treatment adequacy and treatment outcomes in HIV-positive and HIV-negative people in the post-antiretroviral therapy era. Treatment adequacy was determined by measuring two primary endpoints associated with OPSCC survival: time to therapy and total radiation dose. Treatment outcomes were assessed by measuring disease-free and overall survival. We identified a total of 37 HIV-positive and 149 HIV-negative people with OPSCC. HIV-positive people experienced a median delay of 10 days from time of OPSCC diagnosis to start of therapy compared with HIV-negative people [hazard ratio (HR) 0.61, 95% confidence interval (CI) 0.38-0.98]. Total post-radiation dose in HIV-positive people was lower than that in HIV-negative people [58.5 Gray (Gy) versus 64.4 Gy,

Indexed as

AdultAgedAnti-HIV AgentsCarcinoma, Squamous CellCombined Modality TherapyComorbidityConfounding Factors, EpidemiologicDisease-Free SurvivalFemaleHIV InfectionsHIV SeronegativityHIV SeropositivityHuman papillomavirus 16HumansKaplan-Meier EstimateMaleAnti-HIV Agentscancer survivalHIVhuman papillomavirusoropharyngeal squamous cell carcinomatreatment outcomes

Identifiers

PMID31347379
PMCPMC6806360
OpenAlexW2972156848

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.