ArticleJournal of biomedical optics2019
Digital histology with Mueller microscopy: how to mitigate an impact of tissue cut thickness fluctuations.
Article in Journal of biomedical optics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Polarization-Interference Jones Matrix Sensors of Layer-by-Layer Scanning of Polycrystalline Dehydrated Blood Films. Fundamental and Applied Aspects.Sensors (Basel, Switzerland) · 2025Article
- Deep tissue sensing of chiral molecules using polarization-enhanced photoacoustics.Science advances · 2025Article
- 3D polarization-interference holographic histology for wavelet-based differentiation of the polycrystalline component of biological tissues with different necrotic states. Forensic applications.Journal of biomedical optics · 2024Article
- Mechanical stability of polarization signatures in biological tissue characterization.Biomedical optics express · 2024Article
- Mueller-matrix imaging polarimetry elevated by wavelet decomposition and polarization-singular processing for analysis of specific cancerous tissue pathology.Journal of biomedical optics · 2023Article
- Spatial frequency domain Mueller matrix imaging.Journal of biomedical optics · 2022Article
- Birefringence effect studies of collagen formed by nonenzymatic glycation using dual-retarder Mueller polarimetry.Journal of biomedical optics · 2022Article
- Mueller matrix imaging for collagen scoring in mice model of pregnancy.Scientific reports · 2021Article
- High-fidelity and rapid cellular-level Mueller matrix imaging for tissue identification with unstained sections.Biomedical optics express · 2021Article
- Characterization of Mueller matrix elements for classifying human skin cancer utilizing random forest algorithm.Journal of biomedical optics · 2021Article
- Polarimetric imaging microscopy for advanced inspection of vegetal tissues.Scientific reports · 2021Article
- Comparative study of the influence of imaging resolution on linear retardance parameters derived from the Mueller matrix.Biomedical optics express · 2021Article
- Analysis of tissue microstructure with Mueller microscopy: logarithmic decomposition and Monte Carlo modeling.Journal of biomedical optics · 2020Article
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Authors and funding
10 authors.
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Abstract
Mueller microscopy studies of fixed unstained histological cuts of human skin models were combined with an analysis of experimental data within the framework of differential Mueller matrix (MM) formalism. A custom-built Mueller polarimetric microscope was used in transmission configuration for the optical measurements of skin tissue model adjacent cuts of various nominal thicknesses (5 to 30 μm). The maps of both depolarization and polarization parameters were calculated from the corresponding microscopic MM images by applying a logarithmic Mueller matrix decomposition (LMMD) pixelwise. The parameters derived from LMMD of measured tissue cuts and the intensity of transmitted light were used for an automated segmentation of microscopy images to delineate dermal and epidermal layers. The quadratic dependence of depolarization parameters and linear dependence of polarization parameters on thickness, as predicted by the theory, was confirmed in our measurements. These findings pave the way toward digital histology with polarized light by presenting the combination of optimal optical markers, which allows mitigating the impact of tissue cut thickness fluctuations and increases the contrast of polarimetric images for tissue diagnostics.
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