ArticleESC heart failure2019
Echocardiographic assessment of functional mitral regurgitation: opening Pandora's box?
Article in ESC heart failure, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Plausible Functional Diagnostics by Rational Echocardiography in the Assessment of Valvular Heart Disease - Role of Quantitative Echocardiography in the Assessment of Mitral Regurgitation.Frontiers in cardiovascular medicine · 2022Pooled it
- Quantification of mitral regurgitation: from traditional methods to artificial intelligence.Cardiovascular ultrasound · 2026Review
- COAPT Trial at 5 Years: Same Doubts Remain About the Efficacy of Transcatheter Edge-to-Edge in Functional Mitral Regurgitation.Brazilian journal of cardiovascular surgery · 2024Article
- Distinct leaflet-annular remodeling pattern in severe atrial functional mitral regurgitation: a three-dimensional echocardiography study.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2024Article
- Expert proposal to analyze the combination of aortic and mitral regurgitation in multiple valvular heart disease by comprehensive echocardiography.Clinical research in cardiology : official journal of the German Cardiac Society · 2024Review
- An Overview of Sport Participation and Exercise Prescription in Mitral Valve Disease.Journal of cardiovascular development and disease · 2023Review
- Functional Mitral and Tricuspid Regurgitation across the Whole Spectrum of Left Ventricular Ejection Fraction: Recognizing the Elephant in the Room of Heart Failure.Journal of clinical medicine · 2023Review
- Atrial functional mitral regurgitation: prevalence, characteristics and outcomes from the National Echo Database of Australia.Open heart · 2023Article
- Quantification of primary mitral regurgitation by echocardiography: A practical appraisal.Frontiers in cardiovascular medicine · 2023Review
- Echocardiographic assessment of mitral regurgitation: discussion of practical and methodologic aspects of severity quantification to improve diagnostic conclusiveness.Clinical research in cardiology : official journal of the German Cardiac Society · 2021Review
- Long-term clinical and haemodynamic results after transcatheter annuloplasty for secondary mitral regurgitation.ESC heart failure · 2021Article
- Review
- Optimal Quantification of Functional Mitral Regurgitation: Comparison of Volumetric and Proximal Isovelocity Surface Area Methods to Predict Outcome.Journal of the American Heart Association · 2021Article
- Leaning Too Much on the Power of Proximal Isovelocity Surface Area? Don't Forget the Volumetric Method for Quantifying Functional Mitral Regurgitation.Journal of the American Heart Association · 2021Article
- Guide to functional mitral regurgitation: a contemporary review.Cardiovascular diagnosis and therapy · 2021Review
- Disproportionate mitral regurgitation: another myth? A critical appraisal of echocardiographic assessment of functional mitral regurgitation.The international journal of cardiovascular imaging · 2021Review
- Echocardiographic analysis of acute effects of percutaneous mitral annuloplasty on severity of secondary mitral regurgitation.ESC heart failure · 2020Article
- Secondary valve regurgitation in patients with heart failure with preserved ejection fraction, heart failure with mid-range ejection fraction, and heart failure with reduced ejection fraction.European heart journal · 2020Review
- Functional Role of Natriuretic Peptides in Risk Assessment and Prognosis of Patients with Mitral Regurgitation.Journal of clinical medicine · 2020Review
- [Valvular heart disease in patients with chronic kidney disease].Der Internist · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two recent trials of transcatheter mitral-valve repair in patients with functional mitral regurgitation (FMR) presented opposing results for the MitraClip® compared to medical therapy alone. The conflicting results gave rise to intensive discussions about assessment of mitral valve regurgitation (MR). A recent editorial viewpoint provided a potential explanation presenting a new pathophysiologic concept. However, the echocardiographic characterization of both trials' patients is inconsistent and the discussed concepts appear to suffer from plausibility weaknesses. It is well conceivable that limitations in the echocardiographic assessment of the trial patients introduced a bias regarding the selection of patients with severe (or less severe) MR that may be a more plausible explanation for the differences in outcome. We here illustrate our viewpoint regarding the two MitraClip trials and also illustrate the difficulties in assessing functional MR properly. It may indeed be "opening Pandora's box", but we will also make an attempt to provide a solution.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.