ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2019
Noncirrhotic hyperammonemia after deceased donor kidney transplantation: A case report.
Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 13 citations in OpenAlex.
- Refractory Bilateral Tubo-Ovarian Abscesses in a Patient with Iatrogenic Hypogammaglobulinemia.Diagnostics (Basel, Switzerland) · 2023Article
- Recurrent noncirrhotic hyperammonemia causing acute metabolic encephalopathy in a patient with a continent ileocecal pouch: a case report.Journal of medical case reports · 2021Article
- Treatment of Hyperammonemia by Transplanting a Symbiotic Pair of Intestinal Microbes.Frontiers in cellular and infection microbiology · 2021Article
- Prognosis of Patients with Sepsis and Non-Hepatic Hyperammonemia: A Cohort Study.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- Hyperammonemia syndrome due to Ureaplasma infection after liver-kidney transplant.Transplant infectious disease : an official journal of the Transplantation Society · 2020Article
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Authors and funding
9 authors at 1 institution in 1 country.
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Abstract
A 72-year-old woman with end-stage kidney disease due to recurrent urinary tract infections and obstructive uropathy of a solitary kidney presented to our hospital for renal transplantation. She underwent successful transplantation of a deceased donor allograft, but developed acute mental status deterioration on the fifth postoperative day. Her serum ammonia was found to be markedly elevated to 447 μmol/L in the setting of normal hepatic function. She was treated with emergent dialysis and empiric antibiotics targeting urea-splitting organisms, and ultimately made a full neurologic recovery with stable renal allograft function. Noncirrhotic hyperammonemia (NCH) is an exceedingly rare clinical entity but seems to have a predilection for patients who have undergone solid organ transplantation. This report emphasizes the importance of rapid diagnosis and initiation of treatment for NCH, which is associated with a high rate of mortality and irreversible neurological morbidity. We outline the successful workup and management approach for this patient.
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