Evidence map›Paper›PMID 31347176›Full record

ArticleJournal of cellular physiology2020

Inhibition of breast cancer growth via miR-7 suppressing ALDH1A3 activity concomitant with decreasing breast cancer stem cell subpopulation.

Meng Pan, Miao Li, Chengzhong You, Fengshu Zhao, Mei Guo, Hui Xu, Luoyang Li, Ling Wang, Jun Dou

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 50 citations in OpenAlex.

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  13. MiR-7 in Cancer Development.Biomedicines · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Meng PanDepartment of Pathogenic Biology and Immunology, School of Medicine, Southeast University, Nanjing, China.
Miao LiDepartment of Pathogenic Biology and Immunology, School of Medicine, Southeast University, Nanjing, China.
Chengzhong YouDepartment of General Surgery, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.
Fengshu ZhaoDepartment of Pathogenic Biology and Immunology, School of Medicine, Southeast University, Nanjing, China.
Mei GuoDepartment of Pathogenic Biology and Immunology, School of Medicine, Southeast University, Nanjing, China.
Hui XuDepartment of Pathogenic Biology and Immunology, School of Medicine, Southeast University, Nanjing, China.
Luoyang LiDepartment of Pathogenic Biology and Immunology, School of Medicine, Southeast University, Nanjing, China.
Ling WangDepartment of Pathogenic Biology and Immunology, School of Medicine, Southeast University, Nanjing, China.
Jun DouDepartment of Pathogenic Biology and Immunology, School of Medicine, Southeast University, Nanjing, China.ORCID 0000-0001-6944-5874
Southeast University · CNZero to Three · USZhongda Hospital Southeast University · CN

Funding

ISOLATION OF BRAIN ACETYLCHOLINESTERASE TROPHIC FACTORF06TW001746 · FIC · SIERRA BIOMEDICAL RESEARCH CORPORATION · PI PEACOCK, JOHN H · 1991 to 1991
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6 · The paper itself

Abstract

Breast cancer patients with high expression of aldehyde dehydrogenases (ALDHs) cell population have higher tolerability to chemotherapy since the cells posses a characteristic of breast cancer stem cells (BCSCs) that are resistant to conventional chemotherapy. In this study, we found that the ALDH-positive cells were higher in CD44

Indexed as

Aldehyde DehydrogenaseAldehyde OxidoreductasesAnimalsBreastBreast NeoplasmsCell Line, TumorFemaleHumansMiceMicroRNAsNeoplastic Stem CellsXenograft Model Antitumor AssaysAldehyde Dehydrogenasealdehyde dehydrogenase (NAD(P)+)Aldehyde OxidoreductasesMicroRNAsMIRN7-1 microRNA, humanALDH1A3breast cancercancer stem cellsmiR-7subpopulation

Identifiers

PMID31347176
PMCPMC6899543
OpenAlexW2965858630

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.