ArticleAging clinical and experimental research2021
The burden of influenza in older adults: meeting the challenge.
Article in Aging clinical and experimental research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Effectiveness of a theory-informed intervention to increase care home staff influenza vaccination rates: a cluster randomised controlled trial.Journal of public health (Oxford, England) · 2025Trial
- Safety and immunogenicity of a quadrivalent influenza vaccine in adults aged 60 years or above: a phase III randomized controlled clinical study.Human vaccines & immunotherapeutics · 2022Trial
- Aging-Related Morphological Change in Regional Lymph Nodes Promote an Immunosuppressive Microenvironment in Colorectal Cancer.Acta histochemica et cytochemica · 2026Article
- Developing a Latin American Delphi Consensus on Vaccination for Respiratory Diseases in Older Adults.Annals of geriatric medicine and research · 2025Article
- Article
- Influenza strains in focus: global approaches to the diagnosis, treatment, and control of H1N1, H3N2, H7N9, and H9N2.Pathogens and global health · 2025Review
- Age-Related Oxidative Stress and Mitochondrial Dysfunction in Lymph Node Stromal Cells Limit the Peripheral T Cell Homeostatic Maintenance and Function.Aging cell · 2025Article
- Influenza vaccination in older people: a geriatrician's perspective.Aging clinical and experimental research · 2025Review
- Article
- Influenza-Associated Excess Mortality and Hospitalization in Germany from 1996 to 2018.Infectious diseases and therapy · 2024Article
- Association Between Sociodemographic Factors and Vaccine Acceptance for Influenza and SARS-CoV-2 in South Korea: Nationwide Cross-Sectional Study.JMIR public health and surveillance · 2024Article
- Uptake and correlates of influenza vaccine among older adults residing in rural regions of south China: a cross-sectional study.Frontiers in public health · 2024Article
- Exploring the impact of population ageing on the spread of emerging respiratory infections and the associated burden of mortality.BMC infectious diseases · 2023Article
- Influenza as an important factor causing increased risk of patients' deaths, excessive morbidity and prolonged hospital stays.Archives of medical science : AMS · 2023Article
- How aging impacts vaccine efficacy: known molecular and cellular mechanisms and future directions.Trends in molecular medicine · 2022Review
- Nutrition, Immunosenescence, and Infectious Disease: An Overview of the Scientific Evidence on Micronutrients and on Modulation of the Gut Microbiota.Advances in nutrition (Bethesda, Md.) · 2022Review
- Article
- The impact of personal coaching on influenza vaccination among healthcare workers before and during COVID-19 pandemic.Vaccine · 2022Article
- The New Quadrivalent Adjuvanted Influenza Vaccine for the Italian Elderly: A Health Technology Assessment.International journal of environmental research and public health · 2022Article
- Seasonal influenza vaccination among older adults in Jordan: prevalence, knowledge, and attitudes.Human vaccines & immunotherapeutics · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Influenza is an acute respiratory infection for which vaccination is our best prevention strategy. Small seasonal changes in circulating influenza viruses (antigenic drift) result in the need for annual influenza vaccination, in which the vaccine formulation is updated to better match the predominant circulating influenza viruses that have undergone important antigenic changes. Although the burden of influenza infection and its complications is the highest in older adults, vaccine effectiveness is the lowest in this vulnerable population. This is largely due to waning of the immune response with age known as "immune senescence", and presents an important, unmet challenge. Possible strategies to tackle this include adjuvant and high-dose vaccines, and herd immunity induced by greater vaccine uptake.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.