Evidence map›Paper›PMID 31347024›Full record

ArticleJournal of endocrinological investigation2020

Wrist circumference is a biomarker of adipose tissue dysfunction and cardiovascular risk in children with obesity.

C Luordi, E Maddaloni, C Bizzarri, S Pedicelli, S Zampetti, L D'Onofrio, C Moretti, M Cappa, R Buzzetti

Open access · bronzeAbstract read
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In one paragraph

Article in Journal of endocrinological investigation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

C LuordiDepartment of Experimental Medicine, Sapienza University, Viale Regina Elena, 324, 00161, Rome, Italy.
E MaddaloniDepartment of Experimental Medicine, Sapienza University, Viale Regina Elena, 324, 00161, Rome, Italy.
C BizzarriUnit of Endocrinology, Bambino Gesù Children's Hospital, Rome, Italy.
S PedicelliUnit of Endocrinology, Bambino Gesù Children's Hospital, Rome, Italy.
S ZampettiDepartment of Experimental Medicine, Sapienza University, Viale Regina Elena, 324, 00161, Rome, Italy.
L D'OnofrioDepartment of Experimental Medicine, Sapienza University, Viale Regina Elena, 324, 00161, Rome, Italy.
C MorettiDepartment of Experimental Medicine, Sapienza University, Viale Regina Elena, 324, 00161, Rome, Italy.
M CappaUnit of Endocrinology, Bambino Gesù Children's Hospital, Rome, Italy.
R BuzzettiDepartment of Experimental Medicine, Sapienza University, Viale Regina Elena, 324, 00161, Rome, Italy. raffaella.buzzetti@uniroma1.it.ORCID http://orcid.org/0000-0003-1490-6041
Sapienza University of Rome · ITBambino Gesù Children's Hospital · IT

Funding

RICERCA FINALIZZATA 2010 RF-2010-2318911
6 · The paper itself

Abstract

purposeTo evaluate the relationship between wrist circumference, markers of adipose dysfunction, and cardiovascular risk in youths with obesity.

methodsIn this cross-sectional study, we measured body mass composition by dual-energy X-ray absorptiometry, wrist circumference, waist-to-height ratio, fasting blood insulin, glucose, lipid profile, adiponectin, and leptin in 280 children with overweight/obesity and without diabetes (age: 7-18 years). Cardiovascular risk was estimated by "metabolic syndrome score" (MetS score).

resultsStudy participants had median [25th-75th percentile] wrist circumference of 17.5 [16.7-18.5] cm and waist-to-height ratio of 0.62 [0.59-0.67]. Lower adiponectin-leptin ratio was found among subjects in the upper 50th percentiles of wrist circumference [0.17 (0.09-0.36) vs. 0.38 (0.16-0.79); p < 0.001]. Wrist circumference was independently associated with MetS score (r = 0.5 p < 0.001). Among MetS score components, an independent association between wrist circumference HDLc, triglycerides, and systolic blood pressure was found (r = - 0.253 p < 0.001; r =+ 0.204 p < 0.001; r = + 0.403 p = < 0.001, respectively). The coefficient of determination for MetS score was nominally higher when considering wrist circumference as independent variable (Adj-R

conclusionsOur study shows that wrist circumference independently relates to adiponectin-leptin ratio and to the prediction of cardiovascular risk, suggesting it as an efficient and adjunctive anthropometric marker of cardiometabolic risk in children with obesity.

Indexed as

AdiposityWaist CircumferenceAdiponectinAdipose TissueAdolescentBiomarkersBody CompositionBody Mass IndexCardiovascular DiseasesChildCross-Sectional StudiesFemaleFollow-Up StudiesHumansInsulin ResistanceMaleAdiponectinADIPOQ protein, humanBiomarkersAdipokinesCardiovascular riskChildhood obesityInsulin resistanceWrist circumference

Identifiers

PMID31347024
OpenAlexW2963401878

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.