Evidence map›Paper›PMID 31346975›Full record

ArticleVirus genes2019

Identification of hepatitis B virus genotype A/E recombinants in Ghana.

Ceejay L Boyce, Stephaney Willis, Timothy N A Archampong, Margaret Lartey, Kwamena W Sagoe, Adjoa Obo-Akwa, Ernest Kenu, Awewura Kwara, Jason T Blackard

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virus genes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ceejay L BoyceDivision of Digestive Disease, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Stephaney WillisDivision of Digestive Disease, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Timothy N A ArchampongDepartment of Medicine and Therapeutics, School of Medicine and Dentistry, College of Health Sciences, University of Ghana, Accra, Ghana.
Margaret LarteyDepartment of Medicine and Therapeutics, School of Medicine and Dentistry, College of Health Sciences, University of Ghana, Accra, Ghana.
Kwamena W SagoeDepartment of Medical Microbiology, School of Biomedical and Allied Health Sciences, College of Health Sciences, University of Ghana, Accra, Ghana.
Adjoa Obo-AkwaDepartment of Medicine and Therapeutics, School of Medicine and Dentistry, College of Health Sciences, University of Ghana, Accra, Ghana.
Ernest KenuKorle-Bu Teaching Hospital, Accra, Ghana.
Awewura KwaraDivision of Infectious Diseases and Global Medicine, University of Florida, Gainesville, FL, USA.
Jason T BlackardDivision of Digestive Disease, University of Cincinnati College of Medicine, Cincinnati, OH, USA. jason.blackard@uc.edu.ORCID http://orcid.org/0000-0003-2876-3811

Funding

Translational ScienceP30AI042853 · NIAID · MIRIAM HOSPITAL · PI LARRY K BROWN · 1998 to 2026
$51.7M
REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY RESEARCHP30ES006096 · NIEHS · UNIVERSITY OF CINCINNATI · PI YADAV, JAGJIT S · 1992 to 2022
$35.4M
Stem Cell/Organoid and Genome Editing CoreP30DK078392 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Alexander Miethke · 2007 to 2026
$24.4M
Miriam/Brown/Tufts Fogarty AIDS International Training and Research ProgramD43TW000237 · FIC · MIRIAM HOSPITAL · PI CU-UVIN, SUSAN · 1993 to 2014
$10.6M
Training Program in Tuberculosis and HIV Research in GhanaD43TW010055 · FIC · UNIVERSITY OF FLORIDA · PI KWARA, AWEWURA JACOB · 2015 to 2019
$1.5M
Brown/Tufts AIDS International Training and Research Program D43TW000237FIC NIH HHS D43 TW000237FIC NIH HHS D43 TW010055FIC NIH HHS D43TW010055Lifespan/Tufts/Brown CFAR P30AI042853National Institute of Environmental Health Science P30-ES006096NIAID NIH HHS P30 AI042853NIDDK NIH HHS P30 DK078392NIEHS NIH HHS P30 ES006096USAID/HED AEG-A-00-05-00007
6 · The paper itself

Abstract

Hepatitis B virus (HBV) exhibits a high degree of heterogeneity with at least 10 genotypes (A-J) identified to date. Intergenotypic recombination is relatively common. Previously, we investigated HBV drug resistance in HIV/HBV co-infected individuals in Ghana. After identifying multiple circulating genotypes and a novel D/E recombinant, we sought to determine if additional individuals were also infected with recombinant HBV. Partial genome sequences from three individuals were initially identified as genotype A4. Full-length HBV genomes were obtained using rolling circle amplification followed by PCR and shown to cluster with known A/E recombinant viruses. Similar recombination breakpoints were observed in these three individuals suggesting local spread of this novel recombinant HBV in Ghana.

Indexed as

GenotypeRecombination, GeneticAdultCluster AnalysisFemaleGhanaHepatitis BHepatitis B virusHumansMaleMiddle AgedPhylogenyWhole Genome SequencingAfricaGenotypeGhanaHepatitis B virusRecombinant/recombination

Identifiers

PMID31346975
PMCPMC6750976

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.