ArticleClinical oral investigations2020
Impact of different platelet-rich fibrin (PRF) procurement methods on the platelet count, antimicrobial efficacy, and fibrin network pattern in different age groups: an in vitro study.
Article in Clinical oral investigations, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Platelet-rich fibrin vs. buccal advancement flap for closure of oroantral communications: a prospective clinical study.Clinical oral investigations · 2023Trial
- Next-generation platelet concentrate: Alb-PRF outperformed PRP and H-PRF in promoting endothelial function and wound healing.Scientific reports · 2026Article
- In vitro investigation of the effect of laser on platelet-rich fibrins.BMC oral health · 2026Article
- A Comparative Evaluation of Platelet-Rich Fibrin and Platelet-Rich Fibrin Matrix in Terms of pH, Antimicrobial Potential and Histological Presentation: An In vitro Study.Journal of maxillofacial and oral surgery · 2025Article
- Accurate Delivery of Mesenchymal Stem Cell Spheroids With Platelet-Rich Fibrin Shield: Enhancing Survival and Repair Functions of Sp-MSCs in Diabetic Wound Healing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Autologous platelet concentrates as adjuvant in the surgical management of medication-related osteonecrosis of the jaw.Periodontology 2000 · 2025Review
- Differences between first- and second-generation autologous platelet concentrates.Periodontology 2000 · 2025Review
- Advanced platelet rich fibrin demonstrates improved osteogenic induction potential in human periodontal ligament cells, growth factor production and mechanical properties as compared to leukocyte and platelet fibrin and injectable platelet rich fibrin.Oral and maxillofacial surgery · 2024Article
- Can platelet-rich fibrin act as a natural carrier for antibiotics delivery? A proof-of-concept study for oral surgical procedures.BMC oral health · 2023Article
- Can Our Blood Help Ensure Antimicrobial and Anti-Inflammatory Properties in Oral and Maxillofacial Surgery?International journal of molecular sciences · 2023Review
- Non-Interventional Prospective Observational Study of Platelet Rich Fibrin as a Therapy Adjunctive in Patients with Medication-Related Osteonecrosis of the Jaw.Journal of clinical medicine · 2022Article
- Histomorphometric evaluation of human extraction sockets treated with autologous fibrin, sticky bone or biphasic calcium phosphate.Acta odontologica latinoamericana : AOL · 2021Article
- Evaluation of Histological and pH Changes in Platelet-Rich Fibrin and Platelet-Rich Fibrin Matrix: AContemporary clinical dentistryArticle
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesPlatelet-rich fibrin (PRF) procuring protocols have been suggested, differing in speed and time duration. Since different derivation protocols may alter PRF characteristics, the present study was conducted to evaluate the variations in the fibrin network pattern, platelet count, and antimicrobial efficacy of PRF procured using variable centrifugation speeds and time durations in different age groups. MATERIALS AND
methodsSixty healthy subjects participated in the study and were equally divided into three age groups (20-34 years, 35-49 years, 50-65 years). From each age group, total of 6 PRF membranes were fabricated from 10 ml tubes. Three PRF membranes were obtained at 1400, 2800, and 3500 rpm for 8 min while other 3 membranes were obtained after 15 min of centrifugation respectively. The relative centrifugal force (RCF) values were within the spectrum of 228-1425 g. PRF membranes were then subjected to platelet count estimation, antimicrobial activity against oral bacteria, and changes in fibrin network pattern with respect to different age groups and different centrifugation protocols.
resultsHighest platelet concentration, antimicrobial activity, and dense fibrin network were obtained in 20-34 years age group. Intragroup analysis within each group revealed highest platelet count and antimicrobial activity in PRF membranes, obtained at 1400 rpm for 8 min. Denser fibrin network pattern was demonstrated by PRF membranes procured at 3500 rpm for 15 min.
conclusionsPRF properties, i.e., platelet count, antimicrobial efficacy, and fibrin network, are influenced by technical aspects of PRF preparation (RCF value, centrifugation speed, and time) and patient age. CLINICAL RELEVANCE: Based on the finding of present study, it can be implied that lower centrifugation speed and time can increase the platelet concentration and antimicrobial activity of the PRF membrane. Contrarily, lowering the speed and time leads to lesser density fibrin network pattern. Centrifugation protocols thus need to be adapted accordingly.
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