Evidence map›Paper›PMID 31346756›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2019

Subcortical amyloid relates to cortical morphology in cognitively normal individuals.

Shady Rahayel, Christian Bocti, Pénélope Sévigny Dupont, Maude Joannette, Marie Maxime Lavallée, Jim Nikelski, Howard Chertkow, Sven Joubert

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In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Shady RahayelDepartment of Psychology, Université de Montréal, Montreal, Quebec, Canada. shady.rahayel@gmail.com.ORCID http://orcid.org/0000-0001-5786-3278
Christian BoctiDepartment of Neurology, Université de Sherbrooke, Sherbrooke, Quebec, Canada.
Pénélope Sévigny DupontDepartment of Psychology, Université de Montréal, Montreal, Quebec, Canada.
Maude JoannetteDepartment of Psychology, Université de Montréal, Montreal, Quebec, Canada.
Marie Maxime LavalléeDepartment of Psychology, Université de Montréal, Montreal, Quebec, Canada.
Jim NikelskiLady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, Quebec, Canada.
Howard ChertkowLady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, Quebec, Canada.
Sven JoubertDepartment of Psychology, Université de Montréal, Montreal, Quebec, Canada.
Institut Universitaire de Gériatrie de Montréal · CAJewish General Hospital · CAUniversité de Sherbrooke · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAmyloid (Aβ) brain deposition can occur in cognitively normal individuals and is associated with cortical volume abnormalities. Aβ-related volume changes are inconsistent across studies. Since volume is composed of surface area and thickness, the relative contribution of Aβ deposition on each of these metrics remains to be understood in cognitively normal individuals.

methodsA group of 104 cognitively normal individuals underwent neuropsychological assessment, PiB-PET scan, and MRI acquisition. Surface-based cortical analyses were performed to investigate the effects of cortical and subcortical Aβ burden on cortical volume, thickness, and surface area. Mediation analyses were used to study the effect of thickness and surface area on Aβ-associated volume changes. We also investigated the relationships between structural metrics in clusters with abnormal morphology and regions underlying resting-state functional networks and cognitive performance.

resultsCortical Aβ was not associated with cortical morphology. Subcortical Aβ burden was associated with changes in cortical volume, thickness, and surface area. Aβ-associated volume changes were driven by cortical surface area with or without thickness but never by thickness alone. Aβ-associated changes overlapped greatly with regions from the default mode network and were associated with lower performance in visuospatial abilities, episodic memory, and working memory.

conclusionsIn cognitively normal individuals, subcortical Aβ is associated with cortical volume, and this effect was driven by surface area with or without thickness. Aβ-associated cortical changes were found in the default mode network and affected cognitive performance. Our findings demonstrate the importance of studying subcortical Aβ and cortical surface area in normal ageing.

Indexed as

CognitionAgedAged, 80 and overAmyloidBrainBrain MappingFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleNeuropsychological TestsPositron-Emission TomographyAmyloidAmyloid betaCognitive ageingDefault mode networkPittsburgh compound BSubcortical

Identifiers

PMID31346756
OpenAlexW2964335799

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.