ArticleBrain structure & function2019
Age-related hearing loss increases full-brain connectivity while reversing directed signaling within the dorsal-ventral pathway for speech.
Article in Brain structure & function, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 59 citations in OpenAlex.
- Dynamic brain functional connectivity in age-related hearing loss during auditory selective spatial attention.GeroScience · 2026Article
- Neural features underlying high-accuracy classification of amnestic mild cognitive impairment using multi-sensory-evoked potentials.GeroScience · 2026Article
- Association of Age-Related Hearing Loss with Domain-Specific Cognitive Performance in Older Adults.Journal of clinical medicine · 2026Article
- Short-term hearing aid use reduces auditory cortical responses to speech-in-noise listening among older adults with age-related hearing loss.Frontiers in aging neuroscience · 2026Article
- Simultaneous tDCS-rTMS stimulation to regulate the language network and improve language ability in Landau-Kleffner syndrome.Epilepsia open · 2025Article
- Preliminary study on the neural mechanisms of four tone recognition in deaf children using fMRI.Scientific reports · 2025Article
- Impact of age-related hearing loss on decompensation of left DLPFC during speech perception in noise: a combined EEG-fNIRS study.GeroScience · 2025Article
- Resilience and vulnerability of neural speech tracking after hearing restoration.Communications biology · 2025Article
- Aging Impacts Basic Auditory and Timing Processes.The European journal of neuroscience · 2025Article
- Electroencephalogram-based objective assessment of cognitive function level associated with age-related hearing loss.GeroScience · 2024Article
- Aging effects on dual-route speech processing networks during speech perception in noise.Human brain mapping · 2024Article
- Unraveling Spatial-Spectral Dynamics of Speech Categorization Speed Using Convolutional Neural Networks.Brain sciences · 2022Article
- Speech to noise ratio improvement induces nonlinear parietal phase synchrony in hearing aid users.Frontiers in neuroscience · 2022Article
- Unique patterns of hearing loss and cognition in older adults' neural responses to cues for speech recognition difficulty.Brain structure & function · 2022Article
- Sensorineural Hearing Loss Affects Functional Connectivity of the Auditory Cortex, Parahippocampal Gyrus and Inferior Prefrontal Gyrus in Tinnitus Patients.Frontiers in neuroscience · 2022Article
- Aberrant Functional Network of Small-World in Sudden Sensorineural Hearing Loss With Tinnitus.Frontiers in neuroscience · 2022Article
- Article
- Corticothalamic projections deliver enhanced responses to medial geniculate body as a function of the temporal reliability of the stimulus.The Journal of physiology · 2021Article
- Dichotic listening deficits in amblyaudia are characterized by aberrant neural oscillations in auditory cortex.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2021Article
- Hearing and dementia: from ears to brain.Brain : a journal of neurology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Speech comprehension difficulties are ubiquitous to aging and hearing loss, particularly in noisy environments. Older adults' poorer speech-in-noise (SIN) comprehension has been related to abnormal neural representations within various nodes (regions) of the speech network, but how senescent changes in hearing alter the transmission of brain signals remains unspecified. We measured electroencephalograms in older adults with and without mild hearing loss during a SIN identification task. Using functional connectivity and graph-theoretic analyses, we show that hearing-impaired (HI) listeners have more extended (less integrated) communication pathways and less efficient information exchange among widespread brain regions (larger network eccentricity) than their normal-hearing (NH) peers. Parameter optimized support vector machine classifiers applied to EEG connectivity data showed hearing status could be decoded (> 85% accuracy) solely using network-level descriptions of brain activity, but classification was particularly robust using left hemisphere connections. Notably, we found a reversal in directed neural signaling in left hemisphere dependent on hearing status among specific connections within the dorsal-ventral speech pathways. NH listeners showed an overall net "bottom-up" signaling directed from auditory cortex (A1) to inferior frontal gyrus (IFG; Broca's area), whereas the HI group showed the reverse signal (i.e., "top-down" Broca's → A1). A similar flow reversal was noted between left IFG and motor cortex. Our full-brain connectivity results demonstrate that even mild forms of hearing loss alter how the brain routes information within the auditory-linguistic-motor loop.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.