ArticleEcology and evolution2019
Origin and evolution of the major histocompatibility complex class I region in eutherian mammals.
Article in Ecology and evolution, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 28 citations in OpenAlex.
- Climate factors and selection shape MHC class II diversity in a montane wild sheep (Ovis ammon).Immunogenetics · 2026Article
- Extraordinary diversity of antiviral immune-related gene families across 38 bat species.BMC biology · 2026Article
- Inbreeding does not reduce major histocompatibility complex diversity in the banded mongoose.BMC ecology and evolution · 2025Article
- Amino acid insertion in Bat MHC-I enhances complex stability and augments peptide presentation.Communications biology · 2024Article
- Diversity and evolution of the MHC class II DRB gene in the Capra sibirica experienced a demographic fluctuation in China.Scientific reports · 2023Article
- MHC architecture in amphibians - ancestral reconstruction, gene rearrangements and duplication patterns.Genome biology and evolution · 2023Article
- Structure and evolution of the squamate major histocompatibility complex as revealed by twoFrontiers in genetics · 2022Article
- Reconstructing Macroevolutionary Patterns in Avian MHC Architecture With Genomic Data.Frontiers in genetics · 2022Article
- The genome of the Pyrenean desman and the effects of bottlenecks and inbreeding on the genomic landscape of an endangered species.Evolutionary applications · 2021Article
- The giant axolotl genome uncovers the evolution, scaling, and transcriptional control of complex gene loci.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Antigenic variation of SARS-CoV-2 in response to immune pressure.Molecular ecology · 2020Article
- Evolution of major histocompatibility complex class I genes in the sableEcology and evolution · 2020Article
- Article
- Can extreme MHC class I diversity be a feature of a wide geographic range? The example of Seba's short-tailed bat (Carollia perspicillata).Immunogenetics · 2019Article
- Origin and evolution of the major histocompatibility complex class I region in eutherian mammals.Ecology and evolution · 2019Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Major histocompatibility complex (MHC) genes in vertebrates are vital in defending against pathogenic infections. To gain new insights into the evolution of MHC Class I (MHCI) genes and test competing hypotheses on the origin of the MHCI region in eutherian mammals, we studied available genome assemblies of nine species in Afrotheria, Xenarthra, and Laurasiatheria, and successfully characterized the MHCI region in six species. The following numbers of putatively functional genes were detected: in the elephant, four, one, and eight in the extended class I region, and κ and β duplication blocks, respectively; in the tenrec, one in the κ duplication block; and in the four bat species, one or two in the β duplication block. Our results indicate that MHCI genes in the κ and β duplication blocks may have originated in the common ancestor of eutherian mammals. In the elephant, tenrec, and all four bats, some MHCI genes occurred outside the MHCI region, suggesting that eutherians may have a more complex MHCI genomic organization than previously thought. Bat-specific three- or five-amino-acid insertions were detected in the MHCI α1 domain in all four bats studied, suggesting that pathogen defense in bats relies on MHCIs having a wider peptide-binding groove, as previously assayed by a bat MHCI gene with a three-amino-acid insertion showing a larger peptide repertoire than in other mammals. Our study adds to knowledge on the diversity of eutherian MHCI genes, which may have been shaped in a taxon-specific manner.
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