Evidence map›Paper›PMID 31346302›Full record

ArticleProceedings of SPIE--the International Society for Optical Engineering2018

High-Resolution Extremity Cone-Beam CT with a CMOS Detector: Evaluation of a Clinical Prototype in Quantitative Assessment of Bone Microarchitecture.

Q Cao, M Brehler, A Sisniega, S Tilley, M M Shiraz Bhruwani, J W Stayman, J Yorkston, J H Siewerdsen, W Zbijewski

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of SPIE--the International Society for Optical Engineering, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Quantitative Evaluation of Bone Microstructure using High-Resolution Extremity Cone-Beam CT with a CMOS Detector.Proceedings of SPIE--the International Society for Optical Engineering · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Q CaoDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD USA 21205.
M BrehlerDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD USA 21205.
A SisniegaDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD USA 21205.
S TilleyDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD USA 21205.
M M Shiraz BhruwaniDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD USA 21205.
J W StaymanDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD USA 21205.
J YorkstonCarestream Health, Rochester, NY USA.
J H SiewerdsenDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD USA 21205.
W ZbijewskiDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD USA 21205.
Johns Hopkins University · USCarestream (United States) · US

Funding

Quantitative high resolution cone beam CT for assessment of bone and joint healthR01EB018896 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI ZBIJEWSKI, WOJCIECH BARTOSZ · 2014 to 2017
$2.0M
Quantitative imaging biomarkers of radiation-induced bone loss in radiotherapy patientsR21CA208821 · NCI · JOHNS HOPKINS UNIVERSITY · PI MORRIS, CAROL, ZBIJEWSKI, WOJCIECH BARTOSZ · 2016 to 2017
$388k
NCI NIH HHS R21 CA208821NIBIB NIH HHS R01 EB018896
6 · The paper itself

Abstract

purposeA prototype high-resolution extremity cone-beam CT (CBCT) system based on a CMOS detector was developed to support quantitative

methodsThe prototype CMOS-based CBCT involves a DALSA Xineos3030 detector (99

resultsThe CMOS detector achieves ~40% increase in the f20 value (frequency at which MTF reduces to 0.20) compared to the a-Si:H FPD. In the reconstruction domain, the FWHM of a 127 μm tungsten wire is also improved by ~40%. Reconstructions of a cadaveric ankle reveal enhanced modulation of trabecular structures with the CMOS detector and soft-tissue visibility that is similar to that of the a-Si:H FPD system. Correlations of the metrics of bone microarchitecture with gold-standard

conclusionAdoption of a CMOS detector in extremity CBCT improved spatial resolution and enhanced performance in metrics of bone microarchitecture compared to a conventional a-Si:H FPD. The results support development of clinical applications of CMOS CBCT in quantitative imaging of bone health.

Indexed as

bone microarchitectureCMOScone-beam CTextremities imaging

Identifiers

PMID31346302
PMCPMC6657686
OpenAlexW2790582786

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.