Evidence map›Paper›PMID 31346184›Full record

ArticleScientific reports2019

Focused very high-energy electron beams as a novel radiotherapy modality for producing high-dose volumetric elements.

K Kokurewicz, E Brunetti, G H Welsh, S M Wiggins, M Boyd, A Sorensen, A J Chalmers, G Schettino, A Subiel, C DesRosiers and 1 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
11.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 70 citations in OpenAlex.

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  12. Transformative Technology for FLASH Radiation Therapy.Applied sciences (Basel, Switzerland) · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

K KokurewiczSUPA, Department of Physics, University of Strathclyde, G4 0NG, Glasgow, UK.
E BrunettiSUPA, Department of Physics, University of Strathclyde, G4 0NG, Glasgow, UK. enrico.brunetti@strath.ac.uk.
G H WelshSUPA, Department of Physics, University of Strathclyde, G4 0NG, Glasgow, UK.ORCID http://orcid.org/0000-0001-7933-4190
S M WigginsSUPA, Department of Physics, University of Strathclyde, G4 0NG, Glasgow, UK.ORCID http://orcid.org/0000-0001-7804-6146
M BoydStrathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, G4 0RE, Glasgow, UK.
A SorensenStrathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, G4 0RE, Glasgow, UK.
A J ChalmersWolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, Glasgow University, G61 1QH, Glasgow, UK.ORCID http://orcid.org/0000-0002-1746-7278
G SchettinoNational Physical Laboratory, Hampton Road, TW11 0LW, Teddington, Middlesex, UK.ORCID http://orcid.org/0000-0003-3284-3953
A SubielNational Physical Laboratory, Hampton Road, TW11 0LW, Teddington, Middlesex, UK.ORCID http://orcid.org/0000-0002-3467-4631
C DesRosiersIndiana University, School of Medicine, Department of Radiation Oncology, RT 041, Indianapolis, USA.ORCID http://orcid.org/0000-0002-6626-2113
D A JaroszynskiSUPA, Department of Physics, University of Strathclyde, G4 0NG, Glasgow, UK. d.a.jaroszynski@strath.ac.uk.
University of Strathclyde · GBNational Physical Laboratory · GBIndiana University – Purdue University Indianapolis · USUniversity of Glasgow · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The increased inertia of very high-energy electrons (VHEEs) due to relativistic effects reduces scattering and enables irradiation of deep-seated tumours. However, entrance and exit doses are high for collimated or diverging beams. Here, we perform a study based on Monte Carlo simulations of focused VHEE beams in a water phantom, showing that dose can be concentrated into a small, well-defined volumetric element, which can be shaped or scanned to treat deep-seated tumours. The dose to surrounding tissue is distributed over a larger volume, which reduces peak surface and exit doses for a single beam by more than one order of magnitude compared with a collimated beam.

Indexed as

Computer SimulationRadiotherapy DosageElectronsMonte Carlo MethodRadiotherapy

Identifiers

PMID31346184
PMCPMC6658670
OpenAlexW2956794122

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.