ArticleNature communications2019
Lateral dispersion is required for circuit integration of newly generated dentate granule cells.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Characterization of adult hippocampal neurogenesis in the novelbioRxiv : the preprint server for biology · 2025Article
- Advances in intravital imaging of adult neurogenesis in mice.Stem cell reports · 2025Review
- Enriched Environment Reduces Seizure Susceptibility via Entorhinal Cortex Circuit Augmented Adult Neurogenesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Traumatic brain injury promotes neurogenesis at the cost of astrogliogenesis in the adult hippocampus of male mice.Nature communications · 2024Article
- The Gap Junction Inhibitor Octanol Decreases Proliferation and Increases Glial Differentiation of Postnatal Neural Progenitor Cells.International journal of molecular sciences · 2024Article
- DualInternational journal of molecular sciences · 2021Article
- Formation and integration of new neurons in the adult hippocampus.Nature reviews. Neuroscience · 2021Review
- Aging and Rejuvenation of Neural Stem Cells and Their Niches.Cell stem cell · 2020Review
- Article
- Granule Cell Dispersion in Human Temporal Lobe Epilepsy: Proteomics Investigation of Neurodevelopmental Migratory Pathways.Frontiers in cellular neuroscience · 2020Article
- OPETH: Open Source Solution for Real-Time Peri-Event Time Histogram Based on Open Ephys.Frontiers in neuroinformatics · 2020Article
- Early Dendritic Morphogenesis of Adult-Born Dentate Granule Cells Is Regulated by FHL2.Frontiers in neuroscience · 2020Article
- Deciphering Brain Function by Miniaturized Fluorescence Microscopy in Freely Behaving Animals.Frontiers in neuroscience · 2020Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The process of circuit integration of newly-generated dentate granule cells of the hippocampus has been presumed to be a dynamic process. In fact, little is known regarding the initial development of newly generated neurons prior to circuit integration and the significance of this stage for circuit integration. Here, using advanced live imaging methods, we systematically analyze the dynamic dispersion of newly generated neurons in the neurogenic zone and observe that cells that are physically adjacent coordinate their lateral dispersion. Whole-cell recordings of adjacent newly generated neurons reveal that they are coupled via gap junctions. The dispersion of newly generated cells in the neurogenic zone is restricted when this coupling is disrupted, which severely impairs their subsequent integration into the hippocampal circuit. The results of this study reveal that the dynamic dispersion of newly generated dentate granule cells in the neurogenic zone is a required developmental stage for circuit integration.
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Registered trials
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