Evidence map›Paper›PMID 31346037›Full record

ArticleThe Journal of biological chemistry2019

Methyltransferase-like 21c methylates and stabilizes the heat shock protein Hspa8 in type I myofibers in mice.

Chao Wang, Justine Arrington, Anna C Ratliff, Jingjuan Chen, Hannah E Horton, Yaohui Nie, Feng Yue, Christine A Hrycyna, W Andy Tao, Shihuan Kuang

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. METTLing in Stem Cell and Cancer Biology.Stem cell reviews and reports · 2023
    Review
  10. Article
  11. 1-L Transcription in Alzheimer's Disease.Current issues in molecular biology · 2022
    Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. Signaling Pathways That Control Muscle Mass.International journal of molecular sciences · 2020
    Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Chao WangDepartment of Animal Sciences, Purdue University, West Lafayette, Indiana 47907 wangc129@gmail.com.ORCID 0000-0002-4051-364X
Justine ArringtonDepartment of Chemistry, Purdue University, West Lafayette, Indiana 47907.
Anna C RatliffDepartment of Chemistry, Purdue University, West Lafayette, Indiana 47907.
Jingjuan ChenDepartment of Animal Sciences, Purdue University, West Lafayette, Indiana 47907.
Hannah E HortonDepartment of Biological Sciences, Purdue University, West Lafayette, Indiana 47907.
Yaohui NieDepartment of Animal Sciences, Purdue University, West Lafayette, Indiana 47907.
Feng YueDepartment of Animal Sciences, Purdue University, West Lafayette, Indiana 47907.
Christine A HrycynaDepartment of Chemistry, Purdue University, West Lafayette, Indiana 47907.ORCID 0000-0001-9881-2063
W Andy TaoCenter for Cancer Research, Purdue University, West Lafayette, Indiana 47907.
Shihuan KuangDepartment of Animal Sciences, Purdue University, West Lafayette, Indiana 47907 skuang@purdue.edu.ORCID 0000-0001-9180-3180
Purdue University West Lafayette · US

Funding

PTEN Function in Satellite CellsR01AR071649 · NIAMS · PURDUE UNIVERSITY · PI KUANG, SHIHUAN · 2017 to 2021
$1.7M
NIAMS NIH HHS R01 AR071649
6 · The paper itself

Abstract

Protein methyltransferases mediate posttranslational modifications of both histone and nonhistone proteins. Whereas histone methylation is well-known to regulate gene expression, the biological significance of nonhistone methylation is poorly understood. Methyltransferase-like 21c (Mettl21c) is a newly classified nonhistone lysine methyltransferase whose

Indexed as

AnimalsAutophagyFemaleGene Knock-In TechniquesHeat-Shock ProteinsHEK293 CellsHSC70 Heat-Shock ProteinsHumansMaleMEF2 Transcription FactorsMethylationMethyltransferasesMiceMuscle DevelopmentMusclesMyoblastsHeat-Shock ProteinsHSC70 Heat-Shock ProteinsHSPA8 protein, humanHspa8 protein, mouseMEF2 Transcription FactorsMethyltransferasesMETTL21C protein, mouseautophagychaperone-mediated autophagy (CMA)developmentheat shock protein family A (Hsp70) member 8 (HSPA8)Hsc70methyltransferase-like 21c (Mettl21c)molecular chaperonemyocyte enhancer factor 2 (Mef2)myogenesisposttranslational modificationprotein methylationskeletal muscle

Identifiers

PMID31346037
PMCPMC6746458
OpenAlexW2964263751

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.